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Journal of Materials Science and Nanotechnology
Volume 1 Issue 2
Materials-Metals 2017
November 16-17, 2017 Paris, France
13
th
Annual Conference on
Materials Science, Metal and Manufacturing
J Ruben Morones-Ramirez, Mater Sci Nanotechnol 2017, 1:2
J Ruben Morones-Ramirez
Universidad Autonoma de Nuevo Leon, Mexico
Nano-biotechnology strategies and
engineering design approaches towards
the development of smart therapeutics
biomaterials against infectious diseases
T
here is a growing need to enhance our antibacterial
arsenal given the rising incidence of antibiotic
resistance, the emergence of novel virulent pathogens,
and the almost 40-year innovation gap between
introductions of new molecular classes of antibiotics.
In the face of newly infectious organisms and the
global crisis in antibiotic resistance, there is a need
to invigorate the basic science and technology of
antimicrobial development. This work, describes
different engineering approaches to resolve some
of the challenges in antibiotic development. The first
approach involves exploring potentiation of current
antibiotics using novel and naturally existing therapeutic
adjuvants (such as silver and supplementary metallic
micronutrients) based on a better understanding of the
mechanisms of infectious disease, a comprehension of
microbe-therapeutic biochemical interactions as well
as the microbial genetic responses to therapeutics.
The second approach includes some of the work in
progress to develop novel drug delivery systems, using
the interface of Nanotechnology and Synthetic Biology,
to design intelligent and endogenous antimicrobial
therapeutics. The final approach addresses the
commitment to discover novel antimicrobial molecules
and therapies. This work, in the third approach,
describes an innovative mechanism to discover
antimicrobial molecules through the identification of
fruitful competitive biochemical interactions between
a set of microorganisms in synthetic and natural
ecologies.
Recent Publications
• JR Morones-Ramirez, JA Winkler, CS Spina, and
JJ Collins (2013) Silver enhances the activity and
broadens the spectrum of antibiotics against Gram-
negative bacteria. Science Translational Medicine.
5: 190ra81. (2013)
• S Kalghatgi, CS Spina, JC Costello, M Liesa, JR
Morones-Ramirez, S Slomovic, A Molina, OS
Shirihai, and JJ Collins (2013) Clinically relevant
doses of bactericidal antibiotics induce oxidative
damage in mammalian cells via a common
mechanism. Science Translational Medicine. 5:
192ra85.
• JR Morones-Ramirez (2014) Coupling metallic
nanostructures to thermally responsive polymers
allow the development of intelligent responsive
membranes. International Journal of Polymer
Science. 2014: 1-7.
• Garza Gonzalez MT, Barboza Perez D, Vazquez
Rodriguez A, Garcia-Gutierrez DI, Zarate X,
Cantú Cardenas ME, Urraca-Botello LI, Lopez-
Chuken UJ, Trevino-Torres AL, Cerino-Córdoba
FJ, Medina-Ruiz P, Villarreal-Chiu JF, JR Morones-
Ramírez (2016) Metal-induced production of a
novel bioadsorbent exopolysaccharide in a native
Rhodotorula mucilaginosa from the Mexican
Northeastern region. PLoS One. 11(2): e0148430.