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Journal of Materials Science and Nanotechnology | Volume: 3
March 20-21, 2019 | London, UK
Materials Science and Materials Chemistry
2
nd
International Conference on
P
otential applications of nanomaterials in biomedicine are
based on their biocompatibility and inherent nature of
selective cytotoxicity against unwanted living cells such as
hazardous bacteria, cancer cells and pathogenic fungi, whereby
healthy human cells should not be harmed. In order to protect
human cells from being harmed, most in-vitro studies reported
that uncoated nanomaterial concentration of less than 5 mM
is the required concentration that can cause major cell injury
towards hazardous bacteria. In recent years, there has been
great interest in using light-sensitive nanomaterials with unique
optical properties that offers much better toxicity efficacy under
a specific light wavelength irradiation at a low applied power.
This photo-toxicity effect offers a special flexibility and selectivity
by causing a serious cell damage only when the nanomaterials
are localized in the unwanted living cells and then illuminated
with a suitable wavelength without affecting surrounding
normal tissue. Exposing light-sensitive nanomaterials under
localized light irradiation with specified wavelengths in the
biological micro-environment can induce strong photo-catalysis
that produces immense photo-generated charges (negative
electrons and positive holes). These photo-generated charges
promote a series of photo-chemical reactions that generate a
highly cytotoxic reactive oxygen species (ROS) that can kill the
targeted unwanted cells. ROS and dissolved metals ions are
known to cause cell injury including destruction of cell integrity,
damage of cell wall/membrane and destruction of cellular
components (lipids, DNA and proteins). The present session
will cover a review of photo-toxicity of nanomaterials, probable
toxicity mechanisms and future trends, and some sharing of a
research experience on animal and human studies relating to
light sensitive-ZnO nanomaterials.
Speaker Biography
ShahromMahmudobtainedaBSc.degreeinMaterials/CeramicEngineeringfromIowaState
University(Dec1986)andMSc(2004)&Ph.D.(2008)degreesfromUniversitiSainsMalaysia.
Having worked as an Engineer for a decade in MNCs (Thomson, Sumitomo, Nippon Steel,
Acme,Rolnic,IBM),Mahmudwasinvolvedinthemanufacturing,developmentandresearch
of many products (about 1 billion electronic components & ceramics) including magnetic
ferrite cores, MWfilters, metal oxide varistors, CERDIP alumina substrates and ceramic tiles.
As an academic, he has taught over 20 subjects on mathematics, science and engineering
in many offshore degree programmes (Aussie, UK, American) and USM programmes
(BSc, MSc, Ph.D.). His research areas are transdisciplinary involving nanomaterials,
optoelectronics, bacteriology, anti-cancer, bio-composites and nano-fertilizers. Apart
from publishing over 100 publications, Mahmud has received about two dozen awards in
research& innovation and recently obtained one single-inventor patent. His research team,
Zinc Oxide Research & Innovation (ZORI), has been actively engaging in transdisciplinary
research in that ZORI team has published about 80 ISI papers with total IF>110 and
produced three innovative products that won three gold medals. For six consecutive
years, he has served as the Chief Judge of one international innovation competition.
e:
shahromx@usm.myShahromMahmud
Universiti Sains Malaysia, Malaysia
Biological photo-toxicity of nanomaterials towards unwanted living cells