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Journal of Materials Science and Nanotechnology | Volume: 3
March 20-21, 2019 | London, UK
Materials Science and Materials Chemistry
2
nd
International Conference on
P
oly(vinyl)alcohol (PVA) has been employed as a
chemoembolization agent. Herein, PVA hybridized iron
oxide nanoparticles were used for magnetic resonance
imaging and anti-cancer drug delivery towards liver
cancers. Type III-B rotaxane dendrimers (T3B-RDs) are
hyperbranched macromolecules with mechanical bonds
on every branching unit. Here we demonstrate the design,
synthesis, and characterization of first to third (G1–G3),
and up to the fourth (G4) generation (MW > 22,000Da) of
pure organic T3B-RDs and dendrons through the copper-
catalyzed alkyne–azide cycloaddition (CuAAC) reaction.
By utilizing multiple molecular shuttling of the mechanical
bonds within the sphere-like macromolecule, a collective
three-dimensional contract -extend molecular motion is
demonstrated by diffusion ordered spectroscopy (DOSY) and
atomic force microscopy (AFM). The discrete T3B-RDs are
further observed and characterized by AFM, dynamic light
scattering (DLS), and mass spectrometry (MS). The binding
of chlorambucil, a drug for leukemia treatment, and pH-
triggered switching of the T3B-RDs are also characterized by
NMR spectroscopy.
Speaker Biography
Ken Cham-Fai Leung is an Associate Professor and Programme Director at the Department
of Chemistry, The Hong Kong Baptist University (HKBU), Hong Kong SAR, P. R. China. He
concurrently holds the Honorary Associate Professorship at the Faculty of Dentistry, The
University of Hong Kong (HKU). He conducted a three-year postdoctoral research work
in the laboratory of Nobel Laureate in Chemistry, Professor Sir J. Fraser Stoddart. He has
published over 100 research papers in peer-reviewed international journals with over 4,500
times of citation and an h-index of 35.
e:
cfleung@hkbu.edu.hkKen Cham-Fai Leung
The Hong Kong Baptist University, Hong Kong
Novel dendritic and polymer hybrid nanomaterials towards drug delivery