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Journal of Gastroenterology and Digestive Diseases | Volume 3
May 25-26, 2018 | New York, USA
World Liver Conference 2018
Hepatitis C Virus (HCV) is one of the major globally prevalent
pathogen and one of the main leading causes of death
and morbidity. The last estimates of disease burden showed
an increase in Seroprevalence over the last 15 years to 2.8%,
equating to >185 million infections worldwide. Persistent HCV
infection is associated with the development of liver cirrhosis,
hepatocellular cancer, liver failure and death and is basically
the most common cause of death in HIV-positive patients on
highly active antiretroviral therapy. Previous and more recent
studies have reported regional level prevalence estimates, but
always considering a limited number of countries. This study
represent one of the most comprehensive effort to quantify
global HCV epidemiology, using the best available published
data between 2000 and 2015 from 138 countries (about 90% of
the global population), grouped in 20 geographical areas (with
the exclusion of Oceania), as defined by the Global Burden of
Diseases project (GBD). Total global HCVprevalence is estimated
at 2.5% (177.5 millions of HCV infected adults), ranging from
2.9% in Africa and 1.3% in Americas, with a global viraemic
rate of 67% (118.9 millions of HCV RNA positive cases), varying
from64.4% in Asia to 74.8% in Australasia. HCV genotype one is
the most prevalent worldwide (49.1.%), followed by genotype
three (17.9%), four (16.8%) and two (11.0%). Genotypes five
and six are responsible for the remaining <5%. While genotypes
one and three are common worldwide, the largest proportion
of genotypes four and five is in lower-income countries. A more
precise knowledge of HCV genotype distribution will be helpful
to best inform national healthcare models to improve access to
new treatments.
Speaker Biography
Arnolfo Petruzziello is the Head of the Virology and Molecular Biology Unit of National
Cancer Institute, IRCCS Fondazione G Pascale in Naples, Italy. He has completed his
Post-graduation in Microbiology and Virology and PhD in Molecular and Cellular
Pathology. After having completed his Post-doctoral studies at University Federico II
of Naples; he has published numerous research papers in peer-reviewed international
journals and has extended his valuable service towards the scientific community with
his extensive research work. He is also Rewiever and Editorial Board Member for
several international scientific journals and conferences.
e:
Arnolfo Petruzziello
IRCCS Fondazione “G Pascale, Italy
Hepatitis C Virus (HCV) infection: A global epidemiology up-date of the circulation of
HCV genotypes