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Archives of General Internal Medicine | Volume 2
&
April 04-05, 2018 | Miami, USA
International Conference on
Internal Medicine & Practice and Primary Care
International Meeting on
Breast Pathology & Cancer Diagnosis
C
ancer incidence and mortality have been rapidly
increasing in the industrialized world. Breast cancer in
women is one of the major diseases in both developed and
developing countries. Apart from surgery and chemotherapy,
radiotherapy is a most prevalent treatment modality but
frequently observed problems of general toxicity, exorbitant
cost and non-specific action pose profound limitations in
treatment of cancer patients. While considerable technical
improvement has been made in delivering the radiation to
the target tissue but technical limitations yet pose many
daunting challenges. The search for new drugs for cancer
treatment has been a challenging task for pharmaceutical
companies. A predicament is faced in the clinic because
anticancer drug as well as radiation kills equally both cancer
and normal cells of the patients producing undesirable
side effects compelling discontinuation of the treatment.
Research is, therefore, warranted to develop non-toxic and
affordable drugs for effective treatment of cancer patients.
To meet these objectives, our laboratory has actively been
investigating to develop novel drugs from plant kingdom and
targeted approaches to selectively kill the cancer cells while
sparing the normal cells. The results of our studies on MCF
7 and T40D breast cancer lines have shown great promise
of enhancing radio sensitivity of these cell lines to gamma
radiation in vitro. A developing strategy that holds promise
in treatment of cancer patients consists in searching for
natural compounds which can selectively enhance tumor
cell toxicity to radiation but spare normal cells as desired in
clinical settings. Recent research from screening studies has
found some potent phytodrugs from plant kingdom which
display unique ability to cause no or minimal toxicity to
normal cells but remarkably sensitize tumor cells to ionizing
radiation. The mechanism involves the radiation generated
reactive oxygen species (ROS) which trigger induction of
apoptosis (cellular suicide) in tumor cells because of the high
oxidative stress status in these cells. This talk is designed to
present a brief highlight of developing plant based herbal
drugs for improving chemo and radiotherapy of cancer
patients. This talk is based on the recent research results
from our laboratory. A few examples of notable herbals
such as triphala, ellagic acid and silibinin will be given for
the observed increased tumor cytotoxicity in tumor cells
by compounds from plant sources which hold promise of
improving cancer radiotherapy.
Speaker Biography
K P Mishra has completed his BSc from University of Allahabad in 1966 and MSc from
University of Allahabad in 1968. He did his PhD from the University of Gujarat in
1979. He became Vice Chancellor at Nehru Gram Bharati University (Deemed-to-be
University), Allahabad from January 2010 onwards. He served as Ex Head & Senior
Scientist at Radiation Biology and Health Sciences Division, Bhabha Atomic Research
Center, Mumbai and retired as scientific officer H+ and Head of RB & HS Division, BARC
in 2006. He worked as Adjunct Professor at Institute of Technology, Manipal Academy
of Higher Education from 2002-2006. He also worked as Adjunct Professor at Dept. of
Life Sciences, Mumbai University, Mumbai from 2006-2009. He also worked as Visiting
Professor in many universities.
e:
mishra_kaushala@rediffmail.comNovel herbal drugs enhanced radiotoxicity of breast cancer lines with relevance to improving cancer
radiotherapy
K P Mishra
Society For Radiation Research, India