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Journal of Infectious Diseases and Medical Microbiology | Volume 3
November 11-12, 2019 | Singapore
International Conference on
3rd International Conference on
Pathology and Infectious Diseases
Pathology and Oncology Research
Joint Event
&
J Infectious Disease Med Microbiol
| Volume 3
Nuclear inverse polarity papillary lesions lacking myoepithelial cells: a report of two
cases
Shinya Tajima, Ichiro Maeda, Yoshio Aida, Akio Kazama, Akira Endo, Motohiro Chosokabe, Keiko Kishimoto, Koi-
chiro Tsugawa, Masayuki Takagi and Junki Koike
St. Marianna University School of Medicine, Japan
P revious reports have described the occurrence of
apocrine lesions with loss of myoepithelial cells which
were thought to be benign. Here we report 2 cases of
“non-apocrine” papillary lesions lacking myoepithelial cells
associated with interesting immunohistochemistry results
and clinico-pathological features. Both papillary lesions were
lined by a fibrovascular core and nuclear inverse polarity
without nuclear atypia. Loss of myoepithelial cells was
observed by hematoxylin-eosin, Calponin, and p63 staining.
Some reports have indicated that high-molecular-weight
cytokeratin 5/6 and estrogen receptor immunostainings are
important for differentiating benign versus malignant lesions.
Moreover, p63 and MUC3 are important for distinguishing
between papillary lesions according to the differential index
(based on the Allred score) of ([ER total score] + [MUC3 total
score])/([CK5/6 total score] + [p63 total score] + 1). Based on
this analysis, our 2 cases had benign lesions. However, based
on immunopositivity for the cell-cycle marker Cyclin-D1, one
case was negative, and the other case was about 70% weak
positive. Additionally, the Ki-67 index was <1% in both cases,
and no evidence of disease was observed after at most 64
months of follow-up for both cases, despitea lackof additional
treatment. Thus, we propose that lack of myoepithelial cells
in papillary lesions do not necessarily indicatemalignancy and
that the present cases had at the most tumor of uncertain
malignant potential.
Speaker Biography
Shinya Tajima graduated Keio University School of Medicine, then he was
employed as a staff to Department of Pathology at Keio University School of
Medicine.Therehe learnedpathologicalanatomyanddiagnosticpathology.
After two years, he joined Department of Radiology at St. Marianna
University School of Medicine to study breast imaging. And he have
presentedsomescientificexhibitionsaboutradio-pathologicalcorrelationof
the breast in domestic and international congress. Furthermore, he learned
at St. Marianna University Graduate School of Medicine for 4 years. And
afterPhDofradiolo-pathologywasacquired,nowhe isdoingsomeresearch
about the comparison of pathologic features and radiologic imaging
findings and also using pathological knowledge, he is research about cancer
stem cell and circulating tumor cells as assistant professor of St. Marianna
University School of Medicine Department of Pathology and Radiology.
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