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Journal of Infectious Diseases and Medical Microbiology | Volume 3
November 11-12, 2019 | Singapore
International Conference on
3
rd
International Conference on
Pathology and Infectious Diseases
Pathology and Oncology Research
Joint Event
&
J Infectious Disease Med Microbiol
| Volume 3
Notes:
First report of occult hepatitis B infection among ART naive HIV seropositive individuals
in Maputo, Mozambique
A Awa Abdul Carimo
1
, B Eduardo Samo Gudo
2
, C Cremildo Maueia
2
, D Nédio Mabunda
2
, E Lúcia Chambal
1
, F
Adolfo Vubil
2
,G Ana Flora
2
, H Francisco Antunes
3
and
I Nilesh Bhatt
2
1
Maputo Central Hospital, Mozambique
2
Instituto Nacional de Saúde, Mozambique
3
University of Lisbon, Portugal
M
ozambique has no study about the prevalence and
the clinical impact of occult B infection and has the
eighth highest HIV prevalence in the world. HIV is one of the
most recognized risk factor for occult hepatitis B. The aim of
this study was to investigate the frequency and clinical and
laboratory characteristics of OBI in ART naive HIV infected
patients. We conducted a cross-sectional study in two health
facilities withinMaputo city, between June andOctober 2012.
A questionnaire was used to obtain demographics and clinical
data. Serological studies was done in blood samples, such as,
HBV surface antigen (HBsAg), antibodies against HBV surface
antigen (anti-HBs) and antibodies against core antigen (anti-
HBc), as well as a quantification of HBV DNA using real time
PCR.
We find that from the 518 ART-naive HIV-positive subjects,
90.9% (471/518) were HBsAg negative. Among HBsAg
negative, 45.2% (213/471) had isolated anti-HBc antibodies,
and the frequency of OBI among patients with anti-HBc alone
was 8.3% (17/206) (fig 1). A total of 11.8%of patients withOBI
presented elevated HBV DNA level. Frequency of individuals
with APRI score > 2 and FIB-4 score > 3.25 was higher in
patients with OBI as compared not exposed, immune and
anti-HBc alone patients. OBI was not correlated either with
CD4+ T cells count or transaminases levels.
We conclude that OBI is prevalent among HIV patients in
Mozambique, and that the screen testes are not sufficient to
diagnose this patient.
Speaker Biography
AwaCarimo isan internistworking inMaputoCentralHospital,Mozambique,
she has completed her Master thesis from Faculty of Medicine Lisbon
University. She has published 3 papers in reputed journals. She works
in Nephrology department from 2011 as a dialysis supervisor. She is an
assistant teacher in Medicine Faculty, Universidade Eduardo Mondlane
as well as in Instituto Superior de Ciências e Tecnologia de Mozambique.
e:
awacarimo83@gmail.comFlowchart of recruitment and testing of study participants anti-HBc − antibody against HBV
core antigen; anti-HBs- − antibody against HBV surface antigen; DNA – desoxirribonucleic acid;
HBsAg- HBV surface antigen; HBV– hepatitis B virus; HIV– human immunodeficiency virus; OBI-
occult hepatitis B virus infection