immunotherapy-2019-scientifictracks

Note:

Page 15

May 22-23, 2019 | Rome, Italy

OF EXCELLENCE

IN INTERNATIONAL

MEETINGS

YEARS

IMMUNOLOGY

AND CANCER THERAPY

Global Summit on

Immunotherapy 2019

Immunology Case Reports | Volume 3

NEUROMETABOLIC EVIDENCES FOR DIABETES AND INTERMITTENT EXPLOSIVE DISOR-

DER: A CASE REPORT

Ahmet Mithat Tavli

Istanbul University, Turkey

Background:

Despite studies suggesting that increased insulin resistance and higher fasting glucose levels

may secondary lead to glucose hypo metabolism in specific brain regions which may contribute to the devel-

opment of cognitive disturbances during diabetes I-II, the underlying mechanism of diabetes associated im-

pulse control disorders is still unclear. Interestingly, a very recent study has demonstrated that impulse control

disorders (especially intermittent explosive disorder) were significantly associated with the diabetes diagnosis.

Thus, studies have reported that intermittent explosive disorder and borderline personality are associated with

an increase of glucose metabolism in the limbic system and a decrease in prefrontal regions supporting the

role of dynamically interacting cortico-subcortical networks. Besides their key role as a pacemaker for cortical

centres via purely motoric coordination, lentiform nucleus and pons have been also shown to play a significant

role in emotional process in also involving reflexive emotional reactions. This is in line with previous evidences

showing that gray matter volume reductions in neocortical regions may be specific to psychiatric disorders.

These findings together suggest that a disturbance in connectivity between different brain regions, rather

than abnormalities within the separate regions themselves may be responsible for the clinical symptoms of

intermittent explosive disorder.

Case:

Here author describe a 36 year old man, experience the aggressive outburst symptoms one year after he

was diagnosed as type II DM.

Ahmet Mithat Tavli, Immunol Case Rep 2019, Volume 3

Ahmet Mithat Tavli completed his PhD in Selçuk University, Turkey. He is the Director of Neurology Department of Milas Govern-

ment Hospital, Turkey. He studied for two years in Florance Nightingale Hospital and studied for two years in Medipol Experimental

Laboratory in İstanbul. He has over 20 publications in various journals.

BIOGRAPHY