immunotherapy-2019-accepted-abstracts

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IMMUNOLOGY

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Immunology Case Reports | Volume 3

Accepted Abstract

SPECIFIC FEATURES OF IMMUNE COMPLEXES IN PATIENTS WITH SARCOIDOSIS AND

PULMONARY TUBERCULOSIS

Starshinova Anna

1, 2

, Zinchenko Yu

1, 2

, Filatov M

1, 2

, Landa S

1, 2

, Burdakov V

1, 2

and

Yablonskiy P

1, 2

Ministry of Health of the Russian Federation, Russia

St. Petersburg State University, Russia

Background:

Clinical and radiological features of tuberculosis and sarcoidosis are quite overlapping and there-

fore, a diagnostic dilemma often persists. There are no commonly accepted criteria for the diagnosis of sar-

coidosis due to the lack of data on the etiology of the disease. The exclusion of tuberculosis in every patient

with suspected sarcoidosis is a mandatory stage of diagnosis, especially in countries with a high burden of

tuberculosis.

Materials & Methods:

A prospective study was conducted with two groups of patients: Group I (n=50)-pa-

tients with pulmonary sarcoidosis established according to standard criteria; group II (n=28)-patients with pul-

monary tuberculosis with bacterial excretion. The control group (n=24) was presented by healthy subjects. The

examination complex included x-ray, bacteriological, immunological (Mantoux test with two TE and TB.SPOT

test) and histological methods. All patients and healthy subjects were assessed for immune complexes with

the use of the dynamic light scattering (DLS) method and adding of “healthy lung tissue extract” antigens and

specific tuberculosis antigens ESAT-6 and SFP-10

in vitro

Results:

Significant differences were found in determining of specific immune complexes in patients with pul-

monary sarcoidosis and pulmonary tuberculosis. Registration of specific immune complexes formation with

“healthy lung tissue extract” in 100% cases may indicate the autoimmune nature of sarcoidosis. The absence

of the immune complexes formation in response to ESAT-6/SFP-10 antigens can be used for the differential

diagnosis of two diseases. The diagnostic significance of the DLS method was 100% for sarcoidosis and 92.2%

for tuberculosis.

Conclusions:

The data obtained in the study allows not only understanding the etiology of sarcoidosis but also

obtaining new criteria for the differential diagnosis of tuberculosis and pulmonary sarcoidosis.

Immunol Case Rep 2019, Volume 3 | DOI: 10.4066/2591-7366-C2-006