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May 22-23, 2019 | Rome, Italy
OF EXCELLENCE
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IMMUNOLOGY
AND CANCER THERAPY
2
nd
Global Summit on
Immunotherapy 2019
Immunology Case Reports | Volume 3
Accepted Abstract
EFFECTS OF FOOD BORNE MYCOTOXINS ON TOLL LIKE RECEPTOR
Mohammad Rafiqul Islam
1
and
Bumseok Kim
2
1
Bangladesh Agricultural Research Council, Bangladesh
2
Chonbuk National University, South Korea
M
ycotoxins are structurally diverse toxic secondary metabolites produced by the organisms of the Fungus
kingdom. Due to the widespread presence of fungi in the environment, mycotoxins are regarded as an
unavoidable contaminant in food products. Mycotoxins can cause mycotoxic nephropathy, hepatotoxicity, cy-
totoxicity, genotoxicity and induce dysregulation of the immune response and are able to either enhance or
suppress resistance to pathogens. Toll-like receptors (TLRs) are a class of proteins that play a key role in the in-
nate immune system. Once microbes have breached physical barriers such as the skin or intestinal tract muco-
sa, they are recognized by TLRs which activate immune cell responses. In the present study, the effects of food
borne mycotoxins on TLRs have investigated in the female BALB/c mice. Mycotoxins (citrinin, deoxynivalenol
and zearalenone) were orally administered to seven weeks old female BALB/c mice at different dose rate for 14
days, and several immunotoxicity tests were performed. Normalized fold expression of TLRs in immune organs
were differentially expressed. After priming of RAW 264.7 macrophage cell line by different TLR ligands, it was
observed that mycotoxins differentially modulated TLR signalling by increased or decreased production of IL-
1β, IL-10 and TNF-α. These results indicate that mycotoxins have multiple immune modulatory effects on TLRS
in mice that may alter normal functions of immune system.
Immunol Case Rep 2019, Volume 3 | DOI: 10.4066/2591-7366-C2-006