4 / 9
allied
academies
IMMUNOLOGY AND CELL BIOLOGY
BACTERIOLOGY AND INFECTIOUS DISEASES
&
Global Summit on
Global Congress on
J u n e 2 5 - 2 6 , 2 0 1 8 | A m s t e r d a m , N e t h e r l a n d s
Virology Research Journal
|
Volume 2
Page 20
Note:
Joint Event on
T
reg constitute a complex network of T cell subtypes which regulate effector
immune responses. AlthoughCD4+Treg aremost known, in the recent years
several CD8+ Treg subpopulations have been characterized. We identified the
exact phenotype of one of these CD8+ Treg subsets (that is CD8+CD28-CD127-
CD39+), allowing us to specifically recognize these cells
in vivo
and to study
them
ex vivo
. Altered frequency or function of these CD8+ Treg appears to be
pathogenically involved in autoimmune diseases. Moreover, these cells heavily
infiltrate tumors and may circulate in the peripheral blood of cancer patients.
These findings suggest their direct involvement also in the pathogenesis of
cancer through the fostering of tumor immune escape. Recently, remarkable
expansion of CD8+CD28-CD127loCD39+ Treg, whose frequency correlated
with both clinical disease and signs of chronic immune cell activation, was
observed in HIV patients.
Biography
Gilberto Filaci is a PhD holder, is Vice-Director of
the Centre of Excellence for Biomedical Research
and full Professor of Laboratory Techniques for
Medicine at the University of Genoa, Italy. He is
author of more than 90 publications cited over
2500 times, and his publication H-index is 28.
gfilaci@unige.itCD8+ TREG INVOLVEMENT IN THE
PATHOGENESIS OF AUTOIMMUNE,
CANCER AND HIV INFECTIOUS
DISEASE
Gilberto Filaci
University of Genoa, Italy
Gilberto Filaci, Virol Res J 2018, Volume 2