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alliedacademies
Materials Science and Nanotechnology | Volume 2
May 21-22, 2018 | New York, USA
International Conference on
Nanoscience & Technology
Miniaturization of laboratory procedures is opening
new possibilities in medicine by allowing point of care
diagnostics, precision medicine, novel therapeutics, reliable
manufacturing of biologics, as well as applications that
are likely unpredictable a priori. A fundamental challenge,
however, is in the miniaturization of the test-tube. As
compartments get smaller, surface effects begin to dominate
over gravity and handling of fluids requires new strategies
that take advantage of nanoscale effects. Biological systems
provide an inspiration for solving this problem through the
formation of fluid cellular and sub-cellular compartments
defined by lipid bilayers as the boundaries. With this in
mind, we have been fabricating arrays of lipid multilayers on
surfaces such that they can contain a volume of encapsulated
materials such as drugs or other reagents and be externally
addressed and analyzed by knowing their position on the
microarray. This approach is particularly interesting for
miniaturized high throughput screening, where there is
potential to test 50,000 drug candidates for efficacy in cell
culture on the area of a single microtiter plate. Furthermore,
as the lipid multilayers decrease in size novel properties can
be exploited, for instance by using optical interference for
rapid and label free readout.
Speaker Biography
Steve Lenhert is an Associate Professor in the department of Biological Science and
faculty member in the Molecular Biopyscis and Materials Science and Engineering
programs at the Florida State University. His doctoral degree is in Biology from
the University of Muenster. He did postdoctoral research at Karlsruhe Institute of
Tanotechnology in Germany and Northwestern University in the USA performing
research in nanobiotechnology. He has published more than thirty peer reviewed
publications on this subject, and in his tenure at FSU has pioneered the use of arrays
of micro- and nanoscopic lipid droplets for miniaturized high throughput screening and
biosensor arrays.
e:
Miniaturizing the test tube with lipid nanotechnology
Steven Lenhert
Florida State University, USA