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Materials Science and Nanotechnology | Volume 2
May 21-22, 2018 | New York, USA
International Conference on
Nanoscience & Technology
I
nfection is one of the most catastrophic complications
in medicine, esp. orthopedic field. Since in almost all
orthopedic surgeries, we implant a device in the patient’s
body, if an infection happens, due to biofilm formation
and attachment of bacteria to the surface of the implant,
removal of the implant is almost always a must. Many
attempts have been done to prevent this attachment and
biofilm formation, like bactericidal silver coating or antibiotic
coating, but none of them had a promising result. So, we
decided to try to solve this problem with another approach.
If we can prevent the biofilm formation, all the attachment
mechanisms of the bacteria are disrupted. For this goal,
we developed a computational software for multiscale
multiphysics simulation of metallic medical devices to design
medical devices mainly from nano and micro scale which
is connected to macroscale features. Several nanoscale/
microscale/mesoscale physicochemical phenomena could
be simulated in this software i.e. protein and bio-ingredients
adhesion, local corrosion (Pitting and Crevice), mechanically
assisted corrosion cracks/microcracks, wear mechanisms,
ions release via corrosion, surface electrostatic charges,
local stress concentration, oxide layer formation/passive
layer, biomaterials microstructural evolution in contact with
human body and etc. Macroscale computational features in
the software are algorithms for mechanical stress and fluid
dynamics calculations. We have developed a 3D Graphical
User Interface (GUI) for designing overall simulation domain
details and for post-processing. Main computational
algorithms and modules in the software are macroscale
stress strain evolution (numerical solution of conservative
equations), biomaterials microstructural evolution (cellular
automata and phase field), fluid dynamics of human
body (numerical solution of conservative equations),
studying corrosion (multiscale and multiphysics approach),
microcracks formations under stress and corrosive
environment (multiscale and multiphysics approach),
dynamics of bio ingredients in human body i.e. bacteria
and protein (Newtonian approach), simulating infection
physically (multiscale and multiphysics approach).
Speaker Biography
Hamid Reza Seyyedhosseinzadeh is an orthopedic surgeon and an associate professor
at Rowan University and leads the Orthopedic Research Group. His special expertise is
in Hip and Knee arthroplasty and designing Implants for hip and knee. During the past
6 years, he has conducted a large, multi-institutional study on “Ethnic Knee Design”.
Now he is leading the orthopedic research group at Rowan University, with great
emphasis on biomechanical and engineering aspects of orthopedics. In this group, a
novel approach to implant material is underway by designing new “Metamaterials” for
orthopedic implants.
e:
hamid@rowan.eduNano/Meso-scale surface engineering for designing orthopedic implants
Hamid Reza Hosseinzadeh
Rowan University, USA