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alliedacademies
Allied J Med Res 2017
Volume 1 Issue 2 Herbal Medicine 2017
September 01-02, 2017 London, UK
3rd International Conference and Expo on
Herbal & Alternative Medicine
Notes:
Page 22
Wild bitter gourd fruit extracts attenuate
monocyte adhesiveness to pulmonary
epithelial cells and the related mechanisms
Yuh-Lien Chen, Hsin-Ching Sung, Chen-Wei Liu and Ming-Shian Lin
National Taiwan University, Taiwan
Wild bitter gourd (WBG, Momordica charantia L.) is
consumed as a vegetable and has been used as a
traditional herbal medicine in Asia. The previous reports
showed that the noticeable pharmacological properties
of WBG fruit extract (WBGE) have antidiabetic, anti-
inflammatory, anti-tumor and anti-oxidative actions.
However, the anti-inflammatory effects of WBGE on human
lung epithelial cells and the underlying mechanisms have
not been elucidated. The present study investigated the
molecular basis of the effects of WBGE on intercellular
cell adhesion molecule -1 (ICAM-1) expression in alveolar
epithelial A549 cells and wild-type (WT) mice with or
without TNF-α treatment. WBGE significantly decreased
the TNF-α-induced ICAM-1 expression in A549 cells
through the inhibition of NF-κB/IκB phosphorylation and
also decreased leukocyte adhesion. Moreover, WBGE
reduced the ICAM-1 expression in lung tissues of WT
mice with or without TNF-α treatment; these results
suggest that WBGE reduced ICAM-1 expression both in
vitro and in vivo. Based on these findings, WBGE should
be considered a novel therapeutic agent for targeting
epithelial activation in pulmonary inflammation.
Biography
Yuh-Lien Chen has completed her PhD research at Institute of Anatomy and
Cell Biology, College of Medicine, National Taiwan University. Her academic
interests focus on the pathogenesis and therapy of cardiovascular diseases
and inflammation. She is currently a Professor at Institute of Anatomy and Cell
Biology, College of Medicine, National Taiwan University. She has published
more than 90 papers in reputed journals.
Yuh-Lien Chen et al., Allied J Med Res 2017