herbal-medicine-2017-posters-accepted-abstracts

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Allied J Med Res 2017
Volume 1 Issue 2 Herbal Medicine 2017
September 01-02, 2017 London, UK
3rd International Conference and Expo on
Herbal & Alternative Medicine
Page 48
Augmentation of triclabendazole therapy with
herbal extract in ovine fasciolosis
Guesh N, Etsay K, Yohannes T, Endale B, Awet T, Kassaw A and
Yohannes H
Mekelle University, Ethiopia
Fasciola is a major parasite of sheep around Lake
Hashenge that is claimed to cause serious destruction
of liver and liver condemnation (more than 80%) which
lead to loss of profit/market despite its potential nutritional
and price value. Liver infected with Fasciola is hard and
fibrotic and is not fit for human consumption regardless
of its zoonotic potential. Triclabendazole is the drug of
choice for treating fasciolosis but triclabendazole have
no effect in the healing or regeneration capacity of the
already damaged liver by the parasite unless augmented
with other natural herbal preparations which make the
damaged liver heal faster. Therefore, this project was
designed to study the augmentation responses of herbal
extract to triclabendazole therapy which was expected to
facilitate the regeneration and healing process of the liver
of sheep. A total of 12 naturally Fasciola infected sheep
diagnosed with coprological examination were used in
this study. The 12 naturally Fasciola infected sheep were
grouped into three groups (G1=Experimental, treated
with both triclabendazole and the herbal extract bolus;
G2=Experimental, treated only with triclabendazole; and
G3=Control, not treated with either of the treatments)
each containing 4 sheep. Herbal bolus were prepared at
the College of Veterinary Medicine, Mekelle University
and used for augmentation. Three months after the
treatment sheep in all the three groups were coprological
examined. The effect of augmentation was evaluated with
liver function tests, gross pathology and histopathology.
All the data were analyzed using STATA version-11.0
statistical software and P-value of 0.05 was considered
a statistically significant difference for all analysis. Gross
findings showed live Fasciola parasite and severe liver
damage; irregular shaped and rough fibrotic liver; and
liver with slight fibrosis and distended gall bladder in
G3, G2 and G1, respectively. Liver function test results
were higher in the control group (G3) compared to G1
and G2 (P<0.05). Microscopic findings of the tissue
samples revealed liver with very sever necrotized area
with diffused extensive fibrosis (cirrhosis) around the
section of parasite in the middle; liver with moderate
necrotized area with diffused extensive fibrosis (cirrhosis);
and liver with fibrosis (cirrhosis) being degraded and
regeneration of hepatocytes around it in G3, G2 and G1,
respectively. Augmentation of triclabendazole with herbal
extract improves the healing and regeneration capacity of
Fasciola infested liver and thus it should be encouraged.
Allied J Med Res 2017