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August 23-24, 2018 | London, UK
Hematology and Oncology
2
nd
International Conference on
Journal of Hematology and Blood Disorder | Volume 2
Hemotopoietic toxicity and blood diseases induced by benzene exposure
Cheng Peng
The University of Queensland, Australia
B
enzene is a representative compound of volatile organic
compounds (VOCs). As an organic solvent, benzene has
been widely used in various areas such as rubber, plastic,
and petroleum industries. Contamination of benzene may
not only occur in occupational settings but also in general
environment since it is a component in petrol, paints and
cigarette smoke. People are exposed to benzene mainly
through inhalation but digestion and dermal contact may also
lead to benzene exposure. Notably, benzene is an established
environmental leukemogen that can causes haematological
malignancies and has been classified as Group 1 carcinogen
by IARC. Although the toxicity and health effect of benzene
have been extensively studied and documented, the exact
mechanisms of these effects remain to be fully addressed.
This talk will discuss recent progress and gaps in the benzene
metabolism as well as the genetic and epigenetic effects of its
metabolites leading to benzene-induced hemotopoietic toxicity
and blood disorders, particularly acute myeloid leukaemia.
e:
c.peng@uq.edu.au