hematology-2018-posters-abstracts

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August 23-24, 2018 | London, UK

Hematology and Oncology

International Conference on

Journal of Hematology and Blood Disorder | Volume 2

Manifestation of Antiphospholipid Syndrome among Saudi patients; Examining the applicability of

Sapporo

Farjah H AlGahtani

King Saud Universty ,Saudi Arabia

ntiphospholipidsyndrome(APS)isasystematicautoimmune

disease featured with vascular thrombosis and pregnancy

morbidity, which is likely to be under-diagnosed in the clinical

practice. The Sapporo classification criteria of APS was revised

in 2006 and are used as the main diagnosis guideline, which

validity as standardmeasurements is still in debate. Few studies

had been tackled the clinical and laboratory manifestations of

APS among Saudi Arabic population. A total of 72 (90%) females

and 8 (10%) males were included, female-to-male ratio was 9:1.

The mean (±SD) age at diagnosis was 28.1 (± 8.7) years (range

11-63 years). 22 patients (27.5%) fulfilled the revised Sapporo

criteria (definitive APS). There was no significant difference

in the clinical manifestations or treatment between the two

group (p>0.2). However, we found definitive APS cases had

significantly higher percentage of serological manifestation

presence than possible APS cases. Although not reaching

statistical significance, definitive APS cases had higher odds of

experiencing vascular thrombosis (OR=1.61, 95%CI 0.55, 4.71;

P=0.39) and DVT/PE (OR=1.53, 95%CI 0.55, 4.31; P=0.42), and

lower odds of experiencing recurrent DVT/PE (OR=0.67, 95%CI

0.12, 3.81; P=0.65) and pregnancy morbidity (OR=0.63, 95%CI

0.21, 1.92; P=0.42) than the possible APS cases.