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allied
academies
August 27-28, 2018 | London, UK
International Conference on
Healthcare and Health Management
Cardiology and Cardiac Surgery
Joint Event
&
Journal of Public Health Policy and Planning | Volume: 2
Exploratory behavior studies in Rats treated with fruit extract of
Pyrus Communis
Linn
Shahlla Imam
1
, Najma Shaheen
2
, Humera Anser
1
and
Wajiha Iffat
3
1
Jinnah Sindh Medical University, Pakistan
2
University of Karachi, Pakistan
3
Dow University of Health Sciences, Pakistan
Context:
Fruitsareanexcellent sourceofmanynutrients, suchas
minerals, fiber, vitamin and health-promoting phytochemicals,
many of which are still being identified.
Pyrus communis L
. is
a valuable fruit that has been widely used since prehistoric
times. It is a wealth of many antioxidants that combat various
degenerative diseases and provide a number of health benefits.
Objective:
The present study was designed and conducted with
the aim to evaluate the anxiolytic activity of
Pyrus communis
fruit extract using the animal model. Methodology: The hydro-
alcoholic fruit extract of
Pyrus communis
was evaluated for their
phytochemical constituents and the total content of flavonoid
wasdeterminedbythealuminiumchloridecolorimetricmethod.
Quercetinwasusedasastandarddrug.Theanxiolyticactivitywas
evaluated using the open field test and forced swim test (FST).
Result:
The result showed that fruit extract exhibits the positive
anxiolytic effect in open field (p < 0.05), and FST (p < 0.001),
when compared with escitalopram. The phytochemical analysis
of
Pyrus communis
fruit extract revealed the presence of several
bioactive compounds such as flavonoids, sugars, and phenolics.
Conclusion:
The present finding suggests that
Pyrus communis
fruit extract has significant anxiolytic potential. However,
further studies are needed to identify the active principles and
their relationship to biological activities.
Speaker Biography
Wajiha Iffat is presently working as assistant professor in Faculty of pharmacy and
pharmaceuticalsciences,Dowcollegeofpharmacy,DUHS.Shedidhergraduation(B.Pharm)
and post-graduation degree in pharmacy fromUniversity of Karachi. She also holds D.H.M.S
degree. She has obtained M.B.A. (marketing) from K.U.B.S, Karachi University in 2010. She
has recently obtained her Ph.D. degree in Pharmaceutics, under the supervision of Prof. Dr.
Harris Shoaib fromdepartment of Pharmaceutics, Faculty of Pharmacy and Pharmaceutical
Sciences,UniversityofKarachi.Shestartedherprofessionalcareerbyworkingasproduction
control inspector in Abbott Laboratories (Pak) Ltd. She has also worked as trainer in project
“a well-managed GP clinic program” that was launched by IOBM in collaboration with Snofi
Aventis. She started her academic career in 2006 as lecturer. She joined Dow college of
Pharmacy in 2008. Apart from academic activities, she was actively engaged as quality
management system coordinator where her main task was to improve the quality of
education system. She has also served as lead auditor and auditor in DUHS. She has also
served as focal person in execution of various co-curricular and extra-curricular activities.
Shehasaround50publicationstohercredit.Hermainresearchinterestincludesformulation
development and optimization, method development and validation, marketing and
management, pharmaco-economics and pharmacy practice. She has attended and
presented in seminars and symposiums organized by various academics institution.
e:
wajiha.iffat@duhs.edu.pk