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S e p t e m b e r 0 6 - 0 7 , 2 0 1 8 | B a n g k o k , T h a i l a n d
allied
academies
Joint Event on
Global Women Health 2018 & Orthopedics Congress 2018
Archives of General Internal Medicine
|
ISSN: 2591-7951
|
Volume 2
BREAST CANCER, GYNECOLOGY AND WOMEN HEALTH
ORTHOPEDICS AND RHEUMATOLOGY
&
World Congress on
Annual Conference on
Arch Gen Intern Med 2018, Volume 2 | DOI: 10.4066/2591-7951-C3-009
THE EXPRESSION OF TH17 CELL IN PERIPHERAL BLOOD OF CHILDREN
WITH SLE
Zeng Hua-Song
and
Huo Le-Ying
Guangzhou Women and Children’s Medical Center, China
Objective:
To investigate the Th17 cell expression in peripheral blood of children with systemic lupus erythematosus (SLE) and
discuss the role of Thl7 cells and the cytokines in the pathogenesis of SLE.
Methods:
25 children with SLE were enrolled and 15 healthy children as control. Flow cytometry (FCM) was employed to detect
the expression of Thl7 cells in peripheral blood of SLE children (SLE group, n=25), and IL-17, IL-21 levels in plasma were detected
by ELISA.
Results:
Compared with that in control, the frequencies of CD3
+
CD8-IL-17
+
T, CD3
+
CD8-IL-21
+
T cells increased significantly in
SLE patients (P<0.01). The plasma concentrations of IL-17, IL-21 were higher obviously (P<0.01). The SLE activity was positive
correlated with the frequencies of CD3
+
CD8-IL-17
+
T cells (r=0.732，P<0.01), but not with the CD3
+
CD8-IL-21
+
T cells (r=-0.002,
P>0.05).
Conclusions:
Th17 cells and the related cytokines played an important role in the pathogenesis of SLE.