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Journal of Research and Reports on Genetics | Volume 3
November 07-08, 2019 | Melbourne, Australia
Molecular Biology and Genetic Engineering
International Conference on
Notes:
S
teroid hormones have been widely overlooked as
controllers of gene expression. Through the mechanisms of
gene expression (DNA methylation, histone methylation, and
RNAi), we discuss the impact of normal reproductive templates
on the pulsatility and amplitude of potential gene-regulating
treatment protocols. By examining the interactions of estradiol
(E2) andprogesterone (P4) inwomen, we propose that changes
inphysiologicreproductivehormonetemplatesofexposureand
timing can affect fertility and even cancer through the silencing
or amplification of gene products; such as P53 and Bcl-2 in
women. We propose that uncontrolled hormone levels, due
to aging and/or the environment, may be restored to a normal
youthful template of gene expression through the fluctuating
exogenous application of E2 and P4 that mimic the normal
hormonal milieu of reproductive health. We hypothesize that
this may lead to a lower risk of the chronic illnesses of aging
and a better quality of life in patients suffering those conditions.
Speaker Biography
Wiley TS has a B.A. from Webster University and is the CEO and Director
of Wiley Compounding Systems, where she performs research in the area
of theoretical medical understanding of the mechanisms of action for
biological systems including gene regulation, hormonal mechanisms, and
pharmaceutical dependence. She has published six papers and two books
on the effects of hormone deregulation and its effects on genomics and
other medical conditions.
e:
tswiley@hiredbrains.comWiley TS
J T Haraldsen
Wiley Compounding Systems, USA
Understanding the effects of steroid hormone exposure on
regulation of P53 and Bcl-2
Wiley TS et al.
, J Res Rep Genet 2019, Volume 3
DOI: 10.35841/2591-7986-C1-001