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Journal of Gastronenterology and Digestive Diseases | Volume 3
J u n e 2 5 - 2 6 , 2 0 1 8 | D u b l i n , I r e l a n d
GASTROENTEROLOGY
International Conference on
Aditya V Kulkarni et al., J Gastroenterol Dig Dis 2018, Volume 3
COMPARATIVE STUDY OF
CONVENTIONAL SCORING SYSTEMS
(CTP & MELD) WITH VON WILLEBRAND
FACTOR IN PREDICTING PROGNOSIS
IN CIRRHOSIS OF LIVER
Aditya V Kulkarni and L Venkatkrishnan
Antrang Hospital of Gastroenterology and Hepatology, India
Aim: The aim of this study is to compare VWF to CTP and MELD scores to
determine short term morbidity and mortality.
Methods: A prospective observational study enrolling 50 patients with
cirrhosis of liver who were categorized according to CTP and MELD scores.
VWF levels were detected. The levels of VWF were compared with the CTP
and MELD scores in 50 cirrhotic patients. All patients were on 3month follow
up to determine the complications.
Results: In comparison with CTP A, B, C, VWF was elevated in 3.4%, 34.5% and
62.1% respectively (X2=10.89, p<0.01). In MELD score, 78.2% had high VWF
levels (X2=7.17, p<0.01). The mean value of overall complications in patients
with high VWF was 1.48+1.32 (t= 2.19, p<0.05), as compared to CTP and
MELD scores which had amean value of 0.8+ 1.14 and 0.77+1.05 respectively.
In comparison of VWF levels with individual complications and mortality,
spontaneous bacterial peritonitis(SBP) was seen in 27.6% in high VWF
group compared to 4.8% in low VWF group (X2=4.299, p<0.05). Hepatorenal
syndrome(HRS)was present in51.7% patients with high VWF group in
comparison with 23.8% in low VWF group (X2=3.95, p<0.01). Correlation of
VWF levels was also done with the grade of varices. 4,23,20,3 patients had
grade 0,1,2,3varices respectively, among which 6.9%,37.9%,48.3%and6.9%
were in high VWF group (X2=2.35, p=0.502). 9 patients had bleeding of which
five patients had high VWF levels.
Conclusions: VWF was a better predictor of overall three months mortality.
As for individual complications, VWF is better in predicting complications
related to bacterial translocation (SBP, HRS) VWF levels did not correlate with
grade of esophageal varices and fail to predict the risk of bleeding over three
months in the study.
Aditya V Kulkarni is a Gastroenterologist, pres-
ently working as consultant in Antrang Hospital
of Gastroenterology and Hepatology, Kolhapur.
He has finished his Gastroenterology training
in PSG Hospitals, Coimbatore, India. During his
academic carrier he has worked on Von Wille-
brand Factor and its impact on liver disease. He
also has presented posters in United European
Gastroenterology week 2016 in Vienna and in
International Liver Congress 2017, Amsterdam.
He has publications in reputated journals like
Endoscopy and Annals of Hepatobiliary and Pan-
creatic surgery. During His academic years he
has also received awards for best poster and
best oral presentation in state conferences.
BIOGRAPHY