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alliedacademies GASTROENTEROLOGY
International Conference on
J u n e 2 5 - 2 6 , 2 0 1 8 | D u b l i n , I r e l a n d
Journal of Gastronenterology and Digestive Diseases | Volume 3
Page 37
Note:
Stomach cancer is one of the leading places in the structure of the cancer
incidence of gastro-intestinal tract. According to numerous publications in
recent years throughout recorded steady growth of this disease. The aim of
the work was to study the dynamics of exchange of the essential amino acid -
L-tryptophan in patients with stomach cancer and the rationale for monitoring
criteria significant indicators of early diagnosis of cancer pathology and
optimization of pathogenetic therapy.
Methods: 130 patients at the age from 35 till 76 years with the established
diagnosis of stomach cancer were examined and treated using clinical tools and
clinical-morphological methods. Tryptophan metabolites, and its metabolism -
serotonin, 5-OIUK determined by C. Atack, T. Magnusson. Melatonin has been
studied by ELISA with monoclonal antibodies.
Results: Studies of exchange of L-tryptophan in patients with stomach cancer
at the earliest stage of tumor found no statistically significant changes in
the dynamics of serum ammonia, indicant, L -tryptophan and the enzyme
activity TAR P <0.05 was observed while the dynamics of steady increase of
L-tryptophan, and TAR.
Conclusions: Optimization of the pathogenetic therapy of stomach cancer
should include a range of therapeutic interventions aimed at normalization of
the neuroendocrine regulation of metabolism of L-tryptophan, detoxification,
increased antioxidant protection and inhibition of oxidative stress, improving
immunological resistance in combination with surgical and chemotherapeutic
effects. Monitor the effectiveness of therapeuticmeasures can be implemented
to change the dynamics of exchange of the amino acidmetabolite L-tryptophan,
which is of great prognostic significance of the outcome of the disease and
recovery.
Biography
Gramatiuk Svetlana serves as President of
UAB (Ukraine Association of Biobank) that she
co-founded in 2017. She was also the Medical
Director Research Biobank ASK-Health (2015-
2016) and the Ukraine Editor of the journal Ad-
vanced Research Biobank and Pathophysiology
from 2017. Previously, she also established and/
or managed several biobanks in Ukraine. In ad-
dition to her unique expertise in biobanking, she
also completed Master of Science Biobanking
in Medical University Graz and has an in-depth
knowledge of oncology biomarker research in the
position holding from Head Department Medical
and Research Laboratory in the Hrigoriev Radiol-
ogy and Oncology Institute and having completed
a Post-Doctoral Fellowship at the Kharkiv Nation-
al Medical University.
FEATURES OF L-TRYPTOPHAN
METABOLITES IN PATIENTS WITH
STOMACH CANCER
Gramatiuk Svetlana
Ukraine Association of Biobank, UK
Gramatiuk Svetlana, J Gastroenterol Dig Dis 2018, Volume 3