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GASTROENTEROLOGY
International Conference on
J u n e 2 5 - 2 6 , 2 0 1 8 | D u b l i n , I r e l a n d
Journal of Gastronenterology and Digestive Diseases
|
Volume 3
Page 36
T
his study was conducted to assess the anti-tumour properties of grapeseed
extract (GSE) against chemically-induced liver cancer. Administration
of different doses of GSE significantly inhibited foci formation as well as
decreasing the number and the area of placental glutathione-S-transferase
in livers of tumour-induced rats by approximately 4 and 10-fold deductions,
respectively. The extract also induced apoptosis and down regulated histone
deacetylase activity and inflammation makers, such as cyclooxygenase 2, and
inducible nitric oxide synthase expressions in liver. It also induced differential
cell cycle arrests and decreased the viability of HepG2 cells and induced early
and late apoptosis through activating caspase-3 and Bax.
Biography
Amr Amin is a graduate faculty at UAE Univer-
sity who supervised many graduate theses. He
earned his PhD fromUniversity of Illinois at Chica-
go and received a postdoctoral training at Univer-
sity of Pennsylvania School of Medicine. His lab
studies roles of natural products in the treatment
and prevention against cancer. He serves on the
editorial boards and as a reviewer of many inter-
national journals and he is also the recipient of
many national and international awards.
a.amin@uaeu.ac.aeGRAPE SEEDS EFFECT AGAINST DEN
INDUCED LIVER CANCER
Amr Amin
UAE University, UAE
Amr Amin, J Gastroenterol Dig Dis 2018, Volume 3