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J Gastroenterol Dig Dis 2017 | Volume 2, Issue 3
World Gastroenterological &
Gastroenterology and Endoscopy
October 30-31, 2017 | Toronto, Canada
World Congress on
Urinary lipocalin-2 as a potential marker for diagnosis of early hepatocellular carcinoma
Lamyaa Bakery Hamed Ata, Eman Abdel Sameea, Maha El Sabawy, Soha El Shenawy, Nabil Omar
and
Saleh Mahmoud
National Liver Institute, Menoufia University, Egypt
Background:
Diagnosis of hepatocellular carcinoma (HCC)
is particularly complex for nodules between 1 and 2 cm
morphological criteria alone still pose problems for the
differential diagnosis of high grade dysplastic nodules versus
early HCC. Lipocalin-2 (Lcn2) is preferentially expressed in
hepatocellular carcinoma.
Aim:
To determine the possibility of using urinary lipocalin-2
as a potential marker for early detection of HCC.
Methods:
A written informed consent was taken from the
all patients included in our study. Diagnosis of HCC was done
by characteristic vascular enhancement pattern detected
by multislice triphasic spiral CT scan or MRI according to
established diagnostic criteria. Serum samples were taken
for assessment of liver tests, alfa fetoprotein level. Urinary
lipocalin-2 levels were measured using ELISA in patients
with HCC (n=40), patients with liver cirrhosis (n=40) and 40
healthy control subjects.
Result:
The mean age of patients with HCC (59.53±7.90-years
old) was significantly higher than those with cirrhosis or
healthy controls (P\0.01). Males represented 75% (n=30)
in the HCC group. The mean urinary lipocalin level was
significantly higher in the HCC group (3661.43±3258.71 pg/
ml) and it was (238.46±152.89 pg/ ml) in the control group.
Lipocalin-2 had a sensitivity of 95% and a specificity of 100%
with area under the curve (AUC) of 0.950; P\0.001 at a
cut-off value of 860 pg/ml for diagnosis of HCC. However,
a-fetoprotein (AFP) had a sensitivity of 87.5% and a specificity
of 81.1% at a cut-off value of 22 ng/ml. The sensitivity and
specificity of adding AFP with lipocalin 2 at cutoff value 1003
pg/ml for diagnosis of HCC showed the same sensitivity
and high specificity Hepatol Int (2017) 11 (Suppl 1):S1–
S1093 S13123 (95%, 100%), respectively, with PPV, NPV was
(100%), (94.9%), respectively. The area under the curve was
(0.999) and accuracy was (97.4), it was statistically significant
(P value=0.001) and CI= (1.0).
Conclusion:
Urinary lipocalin 2 was more effective than AFP
at detecting presence of early stages of HCC. Measuring
both urinary lipocalin 2 and AFP in serum could be used as
diagnostic markers for HCC.
Speaker Biography
Lamyaa Bakery Hamed Ata is an Assistant lecturer and Phd student of Hepatology
and Gasteroenterology at the National Liver Institute, Menoufiya University, Egypt.
Her main areas of Research Interests and Expertise include Viral hepatitis, Portal
Hypertension and its complications and treatment of Liver cancer and transplantation.
e:
lamiaabakery@yahoo.com