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Arch Gen Intern Med 2017 | Volume 1 Issue 3
allied
academies
International Conference on
FAMILY MEDICINE AND FAMILY PHYSICIANS
October 16-17, 2017 | Toronto, Canada
Background & Aims:
Probiotics have been suggested as a safe
strategy to prevent or reduce the prevalence of GBS recto-
vaginal colonization in pregnant and non-pregnant women.
Probiotics are not yet part of the clinical practice for prevention
of GBS recto-vaginal colonization in women and less physicians
recommend probiotics in prenatal to maintain urogenital
health. The aim of this study was to systematically review the
published controlled randomized trials (RCTs) on the effects of
probiotics on Group B
Streptococcus
recto-vaginal colonization.
Methods:
LiteraturesearchesweremadeuptoSeptember2017.
This systematic review included the published randomized,
double-blind or open label, and placebo-controlled trials on
the effects of probiotics on Group B
Streptococcus
(GBS) recto-
vaginal colonization in pregnant and non-pregnant women. The
PubMed, Medline, HEN, Google Scholar and Cochrane Central
Register of Controlled Trials were searched for keywords.
Results:
A total of four studies, incorporating two pilot RCTs,
were identified as eligible for analysis. Three studies were
conducted in low risk pregnancies. Two of the studies examined
the efficacy of probiotics in pregnant women who presented
as GBS positive at 35-37 weeks of gestation. One of the RCTs
showed significant (GBS) culture change from positive to
negative in 21 women in the probiotic group (42.9%) and in
nine women (18.0%) in the placebo (p=0.007). The sample size
in the two pilot RCTs that aimed to examine the effect of an
oral prenatal probiotic on (GBS) colonization in pregnancy were
too small to draw meaningful conclusions. The randomized
controlled trial in non-pregnant and healthy fertile women
showed a significant reduction of GBS recto-vaginal colonization
in intervention group compare placebo group (p=0.036).
Overall, heterogeneity in choice and dose of probiotics, and
lack of enough statistical information made it impossible to do
ameta-analysis. The Cochrane Collaboration’s tool for assessing
risk of bias showed 3 of 4 reviewed randomized controlled trials
had poor quality.
Conclusion:
There is inadequate evidence relatied to the use
of probiotics for either prevention or treatment of GBS recto-
vaginal colonization in pregnancy. The reviewed studies have
provided suggestion of benefit of probiotics in prevention
of GBS recto-vaginal colonization, nevertheless, available
evidence is not sufficient to support the routine administration
of probiotics to reduce GBS colonization in pregnancy. Further
investigation with better design and larger studies are needed
regarding the efficacy and safety of specific probiotics strains in
pregnancy.
Speaker Biography
Roksana (Roxana) Behruzi is working as an Assistant Professor at McGill University,
Department of Family Medicine, and a Clinician Researcher in the Research Center
at CISSS in Outaouais. She has more than 20 years of experience in both teaching and
clinical research. She has a Master’s degree (MSc) in Midwifery and she completed a
PhD in Public Health at the University of Montreal, during which she obtained many
awards and bursary from CIHR, STIRRHS, Bourse Étude Supériour en Santé Publique,
and Japan Society for the Promotion of Science (JSPS) Fellowship. In 2008, she
accomplished a Fellowship in Japan on maternity care services. She also accomplished
three years Post-doctoral fellowship at the Department of Family Medicine at McGill
University, for which, she was awarded two times the Fond de Recherche en Santé du
Québec (FRSQ). She collaborates with GCP Trials Center in Montreal, in where, she
provide workshops in good clinical practice for clinical research staff. Her latest research
interest is working on the safety and efficacy of probiotics on Group
Streptococcus
(GBS) recto-vaginal colonization in pregnancy.
e:
roksana.behruzi@mcgil.caRoxana Behruzi
McGill University, Canada
Probiotics effect on group B
Streptococcus
(GBS) recto-vaginal colonization in
pregnant and non-pregnant women: A systematic review of published randomized
controlled trials