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Eye Care 2018 & Public Health Congress 2018 Archives of General Internal Medicine | ISSN: 2591-7951 | Volume 2
S e p t e m b e r 0 3 - 0 4 , 2 0 1 8 | L i s b o n , P o r t u g a l
alliedacademies Joint Event on
PUBLIC HEALTH, EPIDEMIOLOGY AND NUTRITION
OCULAR PHARMACOLOGY AND EYE CARE
&
World Congress on
19th International Conference on
Amila Sampath Chandrasekera, Arch Gen Intern Med 2018, Volume 2 | DOI: 10.4066/2591-7951-C4-011
CO-RELATION BETWEEN THE
PERIPAPILLARY MICROVASCULATURE
AND OCULAR PULSE AMPLITUDE IN
GLAUCOMATOUS OPTIC NEUROPATHY
Amila Sampath Chandrasekera
Vision Care Optical Services PVT Ltd, Sri Lanka
Introduction: Although elevated intraocular pressure (IOP) is the main risk
factor for glaucoma, other risk factors and vascular risk factors have been
implicated in the pathogenesis of glaucoma. Impaired microcirculation
in the optic nerve head may contribute to the initiation and progression of
glaucomatous neuropathy. It has been proposed that the main pathologic
changes in glaucoma are in the deep vascular areas in optic nerve head
region.
Objective: To find out the co-relation between ONH microvasculature
perfusion and ocular pulse amplitude and their effect on retinal nerve fiber
layer thickness in glaucomatous optic neuropathy.
Procedure: Study was conducted with 1000 subjects who were diagnosed
as glaucomatous optic neuropathy (based on the Hodapp-Parrish-Anderson
criteria) and grouped as normal tension glaucoma, primary open angle
glaucoma and non-glaucomatous. In every subject peripapilary vascular
perfusion (PVP), ocular pulse amplitude (OPA) and retinal nerve fiber layer
thickness (RNFLT) was measured.
Results: In every group, glaucomatous stages and glaucoma suspects
showed significantly lower blood perfusion index compared with normal eyes
(P≤0.0015). Blood perfusion showed a direct correlation with ocular perfusion
pressure calculated with OPA (P≤0.0123). Similar discrimination capability
PVP compared with RNFL thickness was found in both disease groups.
Conclusion: Impaired blood supply to the optic nerve head peripapillary area,
may cause to develop RNFL thinning which directly leads to glaucomatous
optic neuropathy. Investigations on PVP and OPA will provide a very early
diagnosis and a repeatable follow up baseline for the disease, beyond the
existing methods.
Amila Sampath Chandrasekera has completed the
certificate of ophthalmic assistance in 2011 and com-
pleted diploma in Optometry in 2015 from Academy
of Vision Care Optical Services Sri Lanka. He has pre-
sented oral and poster presentations in academic and
international level poster and won the second place
for best poster award in International Conference in
Clinical and Experimental Ophthalmology 2015. Cur-
rently, he is practicing at the retinal and glaucoma di-
agnostic unit at Vision Care Optical Services PVT Ltd.,
head office Sri Lanka.
BIOGRAPHY