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Eye Care 2018 & Public Health Congress 2018 Archives of General Internal Medicine | ISSN: 2591-7951 | Volume 2
S e p t e m b e r 0 3 - 0 4 , 2 0 1 8 | L i s b o n , P o r t u g a l
alliedacademies Joint Event on
PUBLIC HEALTH, EPIDEMIOLOGY AND NUTRITION
OCULAR PHARMACOLOGY AND EYE CARE
&
World Congress on
19th International Conference on
Engin K N, Arch Gen Intern Med 2018, Volume 2 | DOI: 10.4066/2591-7951-C4-011
IS CLINICAL COURSE OF OPTIC
NEUROPATHY ASSOCIATED WITH
OXIDATIVE DAMAGE AND DYNAMICS OF
ANTIOXIDANT RESPONSE?
Engin K N
Saglik University, Turkey
Optic neuropathy is recognized one of the most frequent causes of
vision loss, which 85% of them are in nonarterial anterior ischemic
optic neuropathy (NAION) form. Glaucoma –another major form of optic
neuropathy, represents a group of neurodegenerative diseases characterized
by structural damage to the optic nerve and the slow, progressive death of
retinal ganglion cells. The nervous system is rich in lipids and oxidative stress
plays a crucial role in neurologic damage. We carried out two multicenter
case control studies to evaluate the oxidative stress profile in large series of
glaucoma and NAION patients. In both studies, a comprehensive systemic
oxidation profile was evaluated in control and patient groups. To assess the
oxidative stress, markers of this destructive process, main antioxidants,
along with SOD and Gpx systems were studied. 8-hydroxy-2’-deoxiguanosine
–marker of oxidative stress related DNA damage in urine, levels were also
determined in the NAION study. In both studies, oxidative stress parameters
varied significantly in the patient groups. For vitamin E and MDA, extremely
significant increases were found. Significant correlations have been found
between clinical findings and oxidative stress parameters. In these studies,
not only clear evidences were obtained regarding optic neuropathy-oxidative
stress connection, but certain interactions of antioxidants that have unique
neurohormone- like activities and regulatory mechanisms were pointed out
as well. A more comprehensive understanding of oxidative damage and
response dynamics will enable us to determine more efficient diagnosis,
follow-up and treatment strategies and facilitate to answer important
questions about optic neuropathies.
Engin K N is an Ophthalmologist and PhD holder in
Biochemistry. He has a strong focus on optic nerve
and his areas of interest are glaucomatous neurode-
generation, oxidative stress, neuroprotection and vita-
min E. Currently, his review article Alpha Tocopherol:
Looking beyond an antioxidant has been cited over 90
times. Along with other academic activities, he is au-
thor of 39 publications, seven special lectures, more
than 70 presentations, and he received six awards. He
is Member of ARVO, EVER, Society of Free Radicals
and Antioxidants Research (Turkey). Since 2005, he
has been serving as an active Member of glaucoma
division of Turkish Ophthalmology Society.
BIOGRAPHY