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Euro Green Chemistry 2019
Journal of Industrial and Environmental Chemistry | ISSN: 2591-7331 | Volume 3
CHEMISTRY AND
EURO GREEN CHEMISTRY
9
th
International Conference on
HIBISCUS FLOWERS AND OLIVE LEAVES EXTRACTS-BASED FORMULATION IN
NEURODEGENERATION: A NETWORK-BASED APPROACH
Matteo Micucci, Maria Frosini, Alberto Chiarini
and
Roberta Budriesi
University of Bologna, Italy
D
espite high clinical heterogeneity, neurodegenerative disorders share many common etiologic features
involving increased ROS formation and inflammation. ROS worsen the progression of the disease owing
to oxidative damage and impaired mitochondrial function. Moreover, the accumulation of misfolded proteins
contributes to the onset and progression of brain inflammatory response, which in turn, increases ROS release
and subsequent oxidative stress (OS). Thus, the reduction of ROS levels may be a promising strategy to delay
neurodegeneration. In this viewmany vegetal extracts and natural compounds endowed with antioxidant (but
not only) properties are currently under clinical investigations. Pres Phytum® is a nutraceutical product com-
posed by leaves- and flowers-extracts of Olea
europaea
L. and Hibiscus
sabdariffa
L., respectively, whose com-
position has already been characterized by HPLC coupled to a UV-Vis and QqQ-Ms detector. The effects of the
components of this natural extracts are widely reported and most of them are mostly due to their antioxidant,
antiapoptotic and anti-inflammatory properties. The aim of this study was to assess neuroprotective effects
of PRES in
in vitro
models of OS-mediated injury. Human neuroblastoma SH-SY5Y cells or rat brain slices were
treated with hydrogen peroxide and neuronal damage as well as Pres Phytum® neuroprotective effects was
assessed. Results showed that Pres Phytum® treatment reverted the increase in sub-diploid, dapi-and annexin
V-positive-cells caused by hydrogen-peroxide challenge in SHSY-5Y cells. Furthermore, Pres Phytum® reduced
ROS formation, as well as changes in the mitochondrial potential (ΔΨm) and caspase-3, 8 and 9 activity caused
by OS. Pres Phytum® neuroprotective effects were confirmed also in rat brain slices. In conclusion, natural com-
pounds still present a great challenge in finding an appropriate treatment to these devastating diseases. In this
regards, the present results suggest the possibility of Pres Phytum® as a new preventive strategy for patients
with high risk of these pathologies.
J Ind Environ Chem 2019, Volume 3 | DOI: 10.4066/2591-7331-C2-012
NEW DEVELOPMENTS AND PROSPECTIVES IN CATALYSIS BY METAL OXIDES
Védrine J C
Sorbonne Université, France
T
his presentation deals with acid-base, redox, oxidation catalytic reactions and more general catalytic
properties of metal oxides and their recent developments in the field of heterogeneous catalysis, a field
of high applied interest. It includes a description of the main metal oxide catalysts used for acid-base (various
reactions), redox (partial and total oxidations) and other reactions and of the main industrial processes using or
expected to use them. Some case studies have been chosen as examples of recent progresses in metal oxides
syntheses leading to new 2D, 3D materials and these reactions. Particular attention is borne on recent and
future researches and perspectives, mainly monitored by actual society regulations related to environmental
issues, uses of biomass derivatives, carbon neutral processes and sustainability.
Accepted Abstracts