euro-green-chemistry-2019-posters-abstracts

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Euro Green Chemistry 2019

Journal of Industrial and Environmental Chemistry | ISSN: 2591-7331 | Volume 3

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EURO GREEN CHEMISTRY

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Sudha T, J Ind Environ Chem 2019, Volume 3 | DOI: 10.4066/2591-7331-C2-012

RECENT TRENDS IN THE SEPARATION OF CHIRAL DRUGS

Sudha T

Adhiparasakthi College of Pharmacy, India

any of the currently used drugs in practice are mixtures of enantiomers. Although they have the same

chemical structure, the enantiomeric forms of a drug can differ in potency, selectivity for receptors, trans-

porters and/or enzymes, rate of metabolism, metabolites, excretion and toxicity, behavior in biological systems

(like pharmacokinetics, bioavailability, efficacy and biopharmaceutical parameters). Therefore, it is important

to promote the chiral separation and analysis racemic drugs in pharmaceutical industry in order to eliminate

the unwanted isomer from the preparation. The use of single enantiomer drugs can potentially lead to simpler

and more selective pharmacologic profiles included therapeutic indices, simpler pharmacokinetics due to dif-

ferent rate of metabolism and decreased drugs interactions. For example, Levorotary–isomer of all β-blockers

is more potent in blocking β- adrenoceptors than their dextrorotary-isomer, such as S-(-)-propranolol is 100

times more active than its R(+)-antipode. In the early period analytical chiral separation was a rather difficult

task and separation methods were not as advanced as today. Nevertheless, it was clear that chiral drugs should

be enantiomer separated and each isomer should be used separately. Enantiomers are separated by using the

modern techniques like HPLC and Chiral HPLC has proven the best methods for the direct separation and anal-

ysis of enantiomers. The physical method and enantioselective immunoassays are used for characterization

of chiral or racemic drugs. The chiral separation of racemic drugs is a necessary operation in pharmaceutical

industry. Therefore the development of new chiral separation techniques and will be a topic subject in aca-

demic research as well as in industrial advance. It is also important to give more information about chiral drugs

especially racemic form to health care professionals in order to help them to finding an optimal treatment and

a right therapeutic control.

Sudha T has completed her PhD from Vels University, India. She is the Associate professor of Adhiparasakthi College of Pharmacy,

affiliated to The Tamil Nadu Dr. MGR Medical University, Tamil Nadu, India. She has over 40 publications that have been cited over

15 times. She has been serving as an Editorial Board Member of reputed journals. She has published the book entitled “PHARMA-

CEUTICAL ANALYSIS-I” by PV books.

BIOGRAPHY