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Euro Green Chemistry 2019 Journal of Industrial and Environmental Chemistry | ISSN: 2591-7331 | Volume 3
Page 28
May 22-23, 2019 | Rome, Italy
OF EXCELLENCE
IN INTERNATIONAL
MEETINGS
YEARS
CHEMISTRY AND
EURO GREEN CHEMISTRY
9th International Conference on
THE CENTERS OF PREMELTONS SIGNAL
THE BEGINNING AND ENDS OF GENES
Premeltons are examples of emergent structures (i.e. structural solitons)
that arise spontaneously in DNA due to the presence of nonlinear ex-
citations in its structure. They are of two kinds: B-B (or A-A) premeltons
format specific DNA-regions to nucleate site-specific DNAmelting. These
are stationary and being globally non-topological, undergo breather mo-
tions that allow drugs and dyes to intercalate into DNA. B-A (or A-B) pre-
meltons, on the other hand are mobile and being globally topological,
act as phase-boundaries transforming B- into A-DNA during the struc-
tural phase-transition. They are not expected to undergo breather-mo-
tions. A key feature of both types of premeltons is the presence of an
intermediate structural-form in their central regions (proposed as being
a transition-state intermediate in DNA-melting and in the B- to A-transi-
tion), which differs from either A- or B-DNA called beta-DNA, this is both
metastable and hyperflexible–and contains an alternating sugar-pucker-
ing pattern along the polymer-backbone combined with the partial-un-
stacking (in its lower energy-forms) of every other base-pair. Beta-DNA is
connected to either B- or to A-DNA on either side by boundaries possess-
ing a gradation of nonlinear structural-change, these being called the
kink and the anti-kink regions. The presence of premeltons in DNA leads
to a unifying theory to understand much of DNA physical-chemistry and
molecular-biology. In particular, premeltons are predicted to define the
5’ and 3’ ends of genes in naked-DNA and DNA in active-chromatin, this
having important implications for understanding physical aspects of the
initiation, elongation and termination of RNA-synthesis during transcrip-
tion. For these and other reasons, the model will be of broader interest to
the general audience working in these areas. The model explains a wide
variety of data and carries within it a number of experimental predictions
all readily testable as will be described in his talk.
Henry Sobell, J Ind Environ Chem 2019, Volume 3
DOI: 10.4066/2591-7331-C2-010
Henry M Sobell has completed his studies at
Brooklyn Technical High School (1948-1952),
Columbia College (1952-1956) and University of
Virginia School of Medicine (1956-1960). Instead
of practicing clinical medicine, then he went to
the Massachusetts Institute of Technology (MIT)
to join Professor Alexander Rich in the Depart-
ment of Biology (1960-1965), where, as a Helen
Hay Whitney Postdoctoral Fellow, he learned the
technique of single crystal X-ray analysis. He then
joined the Chemistry Department at the Uni-
versity of Rochester, having been subsequently
jointly appointed to both the Chemistry and Mo-
lecular Biophysics departments (the latter at the
University of Rochester School of Medicine and
Dentistry), becoming a full tenured Professor in
both departments (1965-1993).
Henry Sobell
University of Rochester, USA
BIOGRAPHY
Keynote Forum | Day 2