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Euro Gastroenterology 2019 & Clinical Pharmacy 2019 Archives of General Internal Medicine | ISSN: 2591-7951 | Volume 3
Page 51
March 25-26, 2019 | Amsterdam, Netherlands
&
GASTROENTEROLOGY AND HEPATOLOGY
4th International Conference on
CLINICAL PHARMACY & PHARMACY PRACTICE
9th World Congress on
Joint Event on
OF EXCELLENCE
IN INTERNATIONAL
MEETINGS
YEARS
OUTCOME OF ACUTE VIRAL HEPATITIS IN DIABETIC AND NON DIABETIC
PATIENTS IN BANGLADESH- REPORT FROM A TERTIARY CENTRE
Mohd Harun Or Rashid1, Khalilur Rahman1 , Mahbubur Rahman Khan1, Tasnova Rashid2
Humaira Rashid3 and Mamun-Al-Mahtab 4
1Rajshahi Medical College Hospital, Bangladesh
2Medical College for Women and Hospital, Bangladesh
3Brac University, Bangladesh
4Bangabandhu Shiekh Mujib Medical University, Bangladesh
Background: Diabetes Mellitus (DM) and Acute Viral Hepatitis (AVH) are common diseases in Bangladesh. Al-
though AVH is a self-limiting pathological entity, DM is endowed with long-term influence on different patho-
logical conditions. The study presented here was designed to assess if DM has any role on clinical course of AVH.
Methods: This cross sectional study was accomplished in Rajshahi Medical College Hospital and Rajshahi Dia-
betic Association Hospital from May 2010 July 2013. A total of 300 patients with AVH were enrolled in this study
and they were divided into two groups; Group-A; patients of AVH with DM (N=140) and Group-B; patients with
AVH without DM (N=160). The clinical and laboratory data of these patients were serially evaluated.
Result: There was no significant difference regarding age, sex, and levels of alanine aminotransferase (ALT) be-
tween two groups. The cause of AVH was hepatitis E virus (HEV) in 100 of 140 patients (71%) in Group A, whereas,
HEV was etiological factor in 112 of 160 patients (70%) of Group-B. However, the clinical course of liver disease
showed marked variation between two groups. Jaundice persisted for more than 6 months in 68 of 140 (49%).
In Group B 149 of 160 Patients (93.12%) became jaundice free within 30 days after attending the hospital. Only
in 11 of 160 patients (6.88%) jaundice persisted for 1 to 3 months. Forty-two patients of Group-A showed evi-
dences of esophageal varices; however, endoscopic assessment did not reveal any abnormality in patients with
Group-B. Moderate to several hepatic fibrosis was seen in 19 of 140 patients with AVH plus DM, whereas, these
were not detected in any patient of Group-B (patient with AVHwithout DM). Evenmore important is the fact that
4 patients of Group-A died of liver failure, whereas there was no mortality in any patient of Group-B.
Conclusion: AVH is regarded as a self-limiting pathological process. The study presented here reveals that pres-
ence of DM in AVH patients drastically alters the clinical course of AVH. In conclusion, all patients with DM with
superimposed AVH should be carefully followed up with possibility of development of severe liver diseases and
even mortality.
Mohd Harun Or Rashid et al., Arch Gen Intern Med 2019, Volume 3 | DOI: 10.4066/2591-7951-C1-023
Mohd Harun Or Rashid has been working as the associate professor, and is the head of the department, department of
hepatology in Rajshahi Medical College, Rajshahi. Treating patients is his foremost duty. In addition, he is an academician
and finds enormous enjoyment with his teaching career. Moreover, he is an active researcher who is very much engaged
with different research projects on hepatology. He runs disease awareness campaigns in the form of cinema, leaflet,
public meeting, screening programme etc.
BIOGRAPHY