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Euro Gastroenterology 2019 & Clinical Pharmacy 2019 Archives of General Internal Medicine | ISSN: 2591-7951 | Volume 3
Page 40
Note:
March 25-26, 2019 | Amsterdam, Netherlands
&
GASTROENTEROLOGY AND HEPATOLOGY
4th International Conference on
CLINICAL PHARMACY & PHARMACY PRACTICE
9th World Congress on
Joint Event on
OF EXCELLENCE
IN INTERNATIONAL
MEETINGS
YEARS
BIOGENIC DIBUTYLTIN (IV) COMPOUNDS DERIVED FROM α-AMINO ACIDS:
SYNTHESIS, BIOIMAGING AND INVESTIGATION OF IN-VITRO ANTICANCER
ACTIVITY
Navjot Singh Batth
GHG Khalsa College, India
Organotin(IV) compounds (1-6) consisting of biogenic coordinating skeleton have been derived from one
pot reaction of dibutyltin oxide, α-amino acids (viz. L-serine, L-isoleucine, L-tryptophan, L-alanine, L-valine,
L-methionine) and 2-hydroxy-4-methoxybenzophenone. The characterization of compounds by FT-IR, NMR (1H,
13C, 119Sn) spectroscopy, mass spectrometry, elemental analyses and single crystal X-ray diffraction (for 1, 2
and 3) confirmed the formation of LSnBu2 (where L is Schiff base ligand) in pure form. Compounds 1 and 2
were found to be enantiomerically pure contrary to 3, which crystallized in the form of enantiomeric pair. All
the compounds exhibited blue-violet emission with a band centred at 470 nm when excited at a wavelength of
365 nm. The fluorescent nature of compounds was explored to investigate their anticancer activity against HeLa
cells. The compounds were found excellent for bioimaging and exhibited good anti-cancer activity. The confocal
fluorescent microscopy of HeLa cells revealed the uptake of 1-6 inside the HeLa cells with higher proportion in
the cytoplasm. Amongst these, compound 1 was found potent anti-cancer agent with IC50 of 8.35 µM.
Navjot Singh Batth, Arch Gen Intern Med 2019, Volume 3 | DOI: 10.4066/2591-7951-C1-023
Navjot Singh Batth is working as an assistant professor in postgraduate department of chemistry in GHG Khalsa College,
Gurusar Sudhar. He has completed his PhD from Panjab University, Chandigarh. His research interests include inves­
tigation of numerous applications of organotin compounds and detection of toxic metal ions/ chemical impurities in
agricultural resources like soil and ground water. His relatively young research career is on route to get further focused
on carrying out quality research oriented towards social benefits. His teaching duties include teaching of spectroscopic
techniques, chemistry of natural products and research supervision of postgraduate students.
BIOGRAPHY