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Euro Gastroenterology 2019 & Clinical Pharmacy 2019 Archives of General Internal Medicine | ISSN: 2591-7951 | Volume 3
Page 20
March 25-26, 2019 | Amsterdam, Netherlands
&
GASTROENTEROLOGY AND HEPATOLOGY
4th International Conference on
CLINICAL PHARMACY & PHARMACY PRACTICE
9th World Congress on
Joint Event on
OF EXCELLENCE
IN INTERNATIONAL
MEETINGS
YEARS
INDICATORS OF METABOLIC
ACTIVITY OF MICRO BIOCENOSIS IN
PATIENTSWITH STOMACH CANCER
The gastric cancer patients have intestinal dysbiosis characterized by in-
hibition of protective and activation of opportunistic microflora against
the background of digestion disorders of carbohydrates, fats, proteins and
accumulation of toxic exchange products, which are an important patho-
genetic factor of activation, induction, proliferation and metaplasia of the
tumor tissue. The presence of Streptococcus bovis stomach cancer patients
may be an early marker of disease progression.
The leading metabolic profile of microbiocenosis in the development of
stomach cancer is the significant accumulation of biogenic amines, which
in turn may have a prognostic value for diagnosis, and the determination
of pathogenetic therapy in patients with gastric cancer. The results of the
study of intestinal microbiocenosis in patients with gastric cancer testify to
the violation of interspecific ratios of the microflora that populate the intes-
tine in normal conditions. Reducing the level of lactobifid bacteria and bac-
teroids, which in the process of life form a milk, acetic, anthraquine, succinic
acid, may be one of the most important causes of changes in the trophic,
protective, metabolic and immunological function of the gastrointestinal
tract, due to the change in intestine of pH medium.
The analysis of the results of the study shows that the failure of anastomosis
in patients with gastric cancer is accompanied by profound disorders of the
metabolism of connective tissue and is confirmed by increased activity of
elastase, collagenolithic activity of blood serum and its content of glycos-
aminoglycans. The activity of elastase and glycosaminoglycans may be a
prognostic criterion for dehiscence of sutures in the course of treatment.
Gramatiuk Svetlana, Arch Gen Intern Med 2019, Volume 3
DOI: 10.4066/2591-7951-C1-022
Gramatiuk Svetlana (MD, PhD) serves as pres-
ident of UAB (Ukraine Association of Biobank)
that she co-founded in 2017. She was also
the medical director of research of biobank
at ASK-Health (2015-2016) and the Ukraine
editor of the Journal of Advanced Research
Biobank and Pathophysiology from 2017.
Previously, Svetlana also has established and
managed several biobanks in Ukraine.
In addition to her unique expertise in bio­
banking, Svetlana also has done master of
science in biobanking from Medical Univer­
sity Graz and has an in-depth knowledge of
oncology biomarker research in the position
holding a position from head of department,
Medical and Research Laboratory in Hrigor-
iev Radiology and Oncology Institute and
having completed a post-doctoral fellowship
at the Kharkiv National Medical University
(department of pathophysiology from
Kharkiv – Ukraine).
Gramatiuk Svetlana
Ukraine Association of Biobank, Ukraine
BIOGRAPHY