ethnopharmacology-physiotherapy-congress-2019-posters

Note:

Ethnopharmacology 2019

& Physiotherapy Congress 2019

Asian Journal of Biomedical and Pharmaceutical Sciences

ISSN: 2249-622X | Volume 9

Page 52

OF EXCELLENCE

IN INTERNATIONAL

MEETINGS

YEARS

March 27-28, 2019 | Amsterdam, Netherlands

PHARMACOLOGY AND ETHNOPHARMACOLOGY

International Conference and Exhibition on

GLOBAL PHYSIOTHERAPY, PHYSICAL

REHABILITATION AND SPORTS MEDICINE

Joint Event on

USE OF SPECIFIC IMMUNE CELLS AND THEIR SIGNALING SYSTEMS FOR

R&D OF CANDIDATE ANTI-TUMOR METASTASIS PHYTOCHEMICALS

Ning-Sun Yang

Agricultural Biotechnology Research Centre, Taiwan

ecent studies showed that a spectrum of innate immune responses, various immune cell types and their cross-

talks, and the associated inflammatory activities are involved in tumor metastasis. Tumor metastasis is now known

to be strongly affected by the surroundings or even “remote” tumor microenvironments. These findings strongly sug-

gest that, by modulating and regulating specific immune cell responses or mechanism-defined, molecular and cellular

inflammation-suppressive activities, we could then design new approaches for therapeutics or treatment of cancer

metastasis. Interestingly, it’s increasingly known and appreciated that various Traditional Chinese Medicines (TCM),

especially some commonly used medicinal herbs, have been claimed with functional specificity (e.g. anti-dermatitis,

suppress severe inflammation, promote wound-healing) and routinely used historically for hundreds to thousands of

years. These activities recently have also been re-established for their“strong anti-inflammatory”activities at the cellu-

lar and tissue levels and are being actively evaluated toward control of specific anti-inflammation at the organ/tissue

levels. With the above observations and understandings, my laboratory has investigated a group of phytoextracts or

the derived pure phytochemicals from specific TCM plants, and evaluated their bioactivities/effects,

in vitro

and

in vivo

on dendritic cells, MDSCs, Th17, Tregs and other immune cell types in mouse models relevant to specific tumor metas-

tasis systems. Experimentally, we employed functional genomics, proteomics, transgenic promoter analysis, cytokine/

chemokine profiling, micro RNA arrays and signaling pathway analysis systems in various cross-examination studies.

Results and findings published in eight key papers during the past several years will be discussed and projected for

future research directions.

Asian J Biomed Pharmaceut Sci 2019, Volume 9 | DOI: 10.4066/2249-622X-C1-018