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Cinzia Casu et al., Arch Gen Intern Med 2018, Volume 2 | DOI: 10.4066/2591-7951-C7-021
APHTHOUS LESIONS IN A CELIAC
POPULATION: AN EPIDEMIOLOGICAL
STUDY
Cinzia Casu, Carla Mannu and Riccardo Botta
Private Practice, Italy
O
ral aphthous ulcers are common lesions of the oral mucosa. Celiac dis-
ease (CD), is an autoimmune disease in which individuals exhibit dam-
ages in the small intestine villi as a consequence of an abnormal immune
response subsequent to the ingestion of gluten. The aim is to report the per-
centage of aphthous lesions in a celiac population of 212 patients. Inclusion
criteria were CD assessed with histological examination, aged between 6 and
12 years. Patients who showed aphthous lesions at the moment of the oral
examination were recorded and the patients were interviewed to find out if
they had had other episodes of ulcers in the last 2 years. 84 patients had no
episodes of mouth ulcers during the last 2 years (39.5%) while 128 had at
least one episode of canker sores (60.5%). In 45 these are localized in the
upper vestibular mucosa (35%), in 31 in the lower vestibular mucosa (24%). In
25 patients, lesions were localized in the tongue (20%), in 15 patients on the
cheek (11.5%) and in 12 cases in the floor of the mouth (9,5%). Discussion.
Saraceno et al. found that RAS appear in 69% of the CD patients, compared
to the 43% in the control group. In a work of Campisi et al. the prevalence
of oral soft tissues lesions was 42% in the coeliac disease patients and 2%
in controls. The results of our study is partially in accordance with previous
epidemiological studies. The difference in Italian diet could be explain the dif-
ference of the epidemiological values in the literature. The importance of the
correlation between aphthous lesion and CD is the basis of study protocols
that include observation of the oral cavity as a means of screening for celiac
disease.
Cinzia Casu has completed a master’s degree in Biolog-
ical Sciences obtained with honors at the University of
Cagliari – Italy. She worked 2 years to Oral Biotechnology
Laboratory (OBL) and to DNA Sequencing Service (DSS),
University of Cagliari. From 2012 to present (six years)
she worked in the diabetes unit in the St Michele Hospital,
Cagliari, as a researcher about Type 1 Diabetes, and as
a local Clinical Study Coordinator of clinical trial and as
a clinical data manager. She, in addition to running dia-
betes research still working with several dentists in the
field of related diseases. She has published more than 10
papers in reputed journals.
ginzia.85@hotmail.itBIOGRAPHY