2 / 10
Page 33
Note:
D e c e m b e r 1 2 - 1 3 , 2 0 1 8 | A b u D h a b i , U A E
Journal of RNA and Genomics
|
Volume 14
Joint Event on
OF EXCELLENCE
IN INTERNATIONAL
MEETINGS
alliedacademies.comYEARS
Epidemiology Congress 2018 & Tropical Medicine Congress 2018
Archives of General Internal Medicine
|
ISSN: 2591-7951
|
Volume 2
&
TROPICAL MEDICINE, INFECTIOUS DISEASES & PUBLIC HEALTH
International Conference on
EPIDEMIOLOGY AND PUBLIC HEALTH
World Congress on
Sumith Roy et al., Arch Gen Intern Med 2018, Volume 2 | DOI: 10.4066/2591-7951-C7-021
PLASMA TRIMETHYLAMINE-N-OXIDE
AND IMPAIRED GLUCOSE REGULATION:
RESULTS FROM THE ORAL INFECTIONS,
GLUCOSE INTOLERANCE AND INSULIN
RESISTANCE STUDY (ORIGINS)
Sumith Roy, Melana Yuzefpolskaya, Renu Nandakumar, Paolo C
Colombo
and
Ryan T Demmer
Columbia University, USA
T
rimethylamine-N-oxide (TMAO) – a gut-microbiota derived metabolite –
is an emerging biomarker of cardiometabolic risk. No studies have inves-
tigated the utility for TMAO as an early biomarker of diabetes risk. We inves-
tigated the association between plasma TMAO and biomarkers of diabetes
risk. The Oral Infections, Glucose Intolerance and Insulin Resistance Study
(ORIGINS) is a longitudinal cohort study among n=300 diabetes-free partic-
ipants enrolled at baseline and re-examined at 2-years. Participants were
men and women (77%) aged 20-55 years (mean=34 10) without: i) Diabetes
Mellitus based on self-report physician diagnosis, fasting plasma glucose
(FPG) 126 mg/dl or HbA1c 6.5% (48mmol/mol); ii) self-reported history of
myocardial infarction, congestive heart failure, stroke or chronic inflammato-
ry conditions. Plasma TMAO was measured using Ultra Performance Liquid
Chromatography-Mass Spectrometry. Baseline FPG, HbA1C and insulin were
measured after an overnight fast. Insulin resistance was defined using HO-
MA-IR. FPG was remeasured two-years after baseline in n=241 participants.
Multivariable generalized linear models regressed FPG, HOMA-IR and HbA1c
on tertiles of TMAO. Multivariable relative risk regressions modeled prediabe-
tes across TMAO tertiles. Mean values of 2-year longitudinal FPG SE across
tertiles of TMAO were 86.6 0.9, 86.7 0.9, 86.4 0.9 (p=0.98). Trends were sim-
ilarly null for FPG, HbA1c and HOMA-IR, cross-sectionally. The prevalence ra-
tio of prediabetes among participants in the 2nd and 3rd TMAO tertiles (vs.
the 1st ) were 1.94 [95%CI 1.09-3.48] and 1.41 [95%CI: 0.76-2.61]. TMAO lev-
els are modestly associated with an increased prevalence of prediabetes in a
nonlinear fashion but not with insulin resistance or longitudinal FPG change.
Sumith Roy is an experienced doctoral researcher with
a demonstrated history of working in the higher educa-
tion industry. She is skilled in Statistics, Research, Clinical
Research, Medical Education, and Life Sciences. She is
a strong research professional with a Master of Public
Health (MPH) focused in Epidemiology from New York
Medical College.
ssr2160@cumc.columbia.eduBIOGRAPHY