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Page 8
allied
academies
September 10-11, 2018 | Paris, France
&
Joint Event
Otolaryngology: ENT Surgery
6th International Conference on
Cell & Stem Cell Research
World Congress and Expo on
Journal of Otolaryngology Online Journal | Volume 8
Food-derived antioxidants are being increasingly investigated
for their therapeutic benefits, and the development of food-
derived products with anti-oxidative and anti-inflammatory
activities for topical oral wound healing has been very attractive.
Topical application of food-derived antioxidants, such as quercetin,
melatonin, anthocyanins, may provide local or regional effects
but they are not possible without effective delivery. Challenges
in the delivery of active substances to the oral mucosa include
the function of the mouth (mastication, swallowing), salivary
secretion, enzymatic degradation and mucociliary clearance.
Mucoadhesive formulations using biocompatible substances
are designed to overcome these challenges in the oral cavity.
In addition, food-derived antioxidants are usually labile to
oxidative damage. Therefore, it is essential that a topical oral
product with acceptable mucoadhesive and biocompatible
properties also protects the antioxidant components from the
oxidative environment. Combinations of mucoadhesive gels with
embedded niosomes, non-ionic surfactant vesicles, provides
this protection via niosomal encapsulation of the food-derived
antioxidants. These noisome gels are prescreened for their
physicochemical characteristics before in vitro, in vivo and cell
studies and clinical trials. Case studies that emphasize topical
oral anthocyanins and transmucosal melatonin are focused.
Speaker Biography
PripremA has completed her PhD at the age of 32 years from the Robert Gordon University,
UK. She is the director of Melatonin Research Group and an academic staff at the faculty of
pharmaceutical science, Khon Kaen University, Thailand. She has over 40 publications that
have been published in international journals and conferences and she has been serving as
an editorial board member of several journals.
e:
Priprem A
Melatonin Research Group - Khon Kaen University, Thailand
Wound healing with topical food-derived antioxidants in noisome gel
Priprem A, ENT and Stem Cell 2018, Volume 8
DOI: 10.4066/2250-0359-C1-001
Notes: