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Journal of Diabetology | Volume 3
Annual Summit on
Diabetes, Obesity & Heart
Diabetes, Endocrinology and Metabolic Syndrome
International Conference on
Joint Event
&
March 07-08, 2019 | London, UK
M
etabolic syndrome (MetS) is a collection of various
interrelated risk factors that appear to have an impact
as development of atherosclerotic cardiovascular disease
(CVDs). Epidemic of childhood and adolescent’s obesity has
increased interest in the metabolic syndrome (MS) due to the
potential projection into adulthood. The prevalence of MS in
adolescents has been estimated to be 6.7% in young adults
and 4.2% in adolescents. We aimed to study the MetS in
children and adolescents with respect to metabolic changes.
The international Diabetes Federation criteria were used for
the selection of cases. Serum paraoxonase 1 (PON1) activities
were measured using spectrophotometer. Statistical analysis
was done using MyStat statistical software. Serum PON1
arylesterase (ARE) and lactonase (LACT) activities were found to
be reduced significantly in patients with MetS than in controls.
Regression analysis showed a significant correlation between
PON1 activities and body mass index. Area under curve (AUC)
found to increase from HDL to PON1 ARE to PON1 LACT. From
the present study, it is clear that in children and adolescents,
reduction in PON1 activities in MetS is mainly due either to
abnormalities with synthesis or secretion of HDL cholesterol or
oxidative stress as a consequence of excess production of the
free radicals. This study also iterates that it is the quality and
not the quantity of HDL cholesterol which is important while
studying the pathophysiology of MetS.
Speaker Biography
Mohit Vijay Rojekar has completed his MD from SRTR Govt Medical College, Ambajogai,
India. Now he is Associate Professor in the Dept of Biochemistry at Rajiv Gandhi Medical
College and director of the Central Clinical Biochemistry Lab at Chhatrapati Shivaji Maharaj
Hospital.Hehastohiscreditmorethan20publications invariousnationaland international
journals. He is on editorial and advisory board of many reputed international journals. He
also serves on reviewer boards of many well-known reputed international journals.
e:
drmohi44@gmail.comMohit Vijay Rojekar
Rajiv Gandhi Medical College, India
Paraoxonase activity in metabolic syndrome in Children and Adolescents