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Journal of Diabetology | Volume 3
Annual Summit on
Diabetes, Obesity & Heart
Diabetes, Endocrinology and Metabolic Syndrome
International Conference on
Joint Event
&
March 07-08, 2019 | London, UK
T
he oxidative stress and hyperlypidimia are important
factors in the pathogenesis and development of
atherosclerosis and type 2 diabetes. The hydroxyl free radicals
are involved in the peroxidative damage to lipoproteins in the
blood leading to the development of atherosclerosis. Further,
in hyperglycemic patients, the occurrence of several non-
enzymatic glycosylations accompanied by glucose oxidation
leadingtotheformationofOH
•
andO
2-
radicalsthroughcatalysis
by Cu
2+
and Fe
2+
ions is the major risk factor of cardiac disorder
in these patients. Moreover, the decrease in the bioavailability
of vascular nitric oxide due to hronic hyperglycemia, insulin
resistance and abnormal lipoprotein profiles lead to the risk of
atherosclerosis. Thus, an agent lowering the cholesterol along
with anti-oxidant activity and anti-diabetic activity should
be able to protect endothelial and myocardial function and
thus may be a good anti-atherosclerotic agent. Tryptophan
derivatives are known to stabilize cell membranes that help
to resist free radical damage due to their function as a free
radical scavenger and anti-oxidants. The hydrazones as well
as carboxamides have been versatile building blocks in the
clinically used pharmaceuticals in the treatment of diabetes,
obesity, metabolic syndrome (dyslipidemia) and CVD’s. In view
of above substituted oxopropanylindole hydrazones were
synthesized and evaluated for anti-oxidant, anti-dyslipidemic,
anti-adipogenic and anti-hyperglycemic activity where the
most promising compound showed 44% reduction in lipid
accumulation and 20.5% and 24.3% reduction in blood glucose
at 5h and 24h respectively, as compared to standard drug
metformin.
Speaker Biography
Mridula Saxena is currently working as Head of the Department of Chemistry, Amity
University, India. She is actively involved in teaching and drug discovery research. She
received her PhD degree at Central Drug Research Institute, Lucknow and has been
associated both with teaching and research from the last 40 years. She has more than 32
papers and review/book articles in national and international journals, and 4 patents to her
credit. She has visited many countries like, Germany, Hong Kong, China, Turkey, Slovenia,
South Korea, Montenegro, Greece, Russia and Dubai for presenting her work.
e:
drmridula.saxena@gmail.comMridula Saxena
Amity University, India
Substituted Oxopropanylindole Hydrazones as potential lipid lowering, anti-oxidant
and anti-hyperglycemic agents