emerging-diseases-influenza-2018-accepted-abstracts

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alliedacademies
Microbiology: Current Research
Volume 2
International Conference on
Emerging Diseases, Outbreaks & Case Studies
&
16 th Annual Meeting on March 28-29, 2018 | Orlando, USA Influenza
Stem cell therapy has been suggested as a novel treatment
for the management of Parkinson’s diseases. The previous
studies demonstrated that the pluripotent embryonic stem
cells and adult stem cells are capable of differentiating into
dopaminergic neurons types’. Recently, stem cells were
isolated from human endometrium, using dopaminergic
neurons differentiation medium. Herein, we postulate that
because of the outcome and complication of the other
sources of stem cells, stem cell therapy through application
of endometrial stem cells can open a new horizon for the
treatment of neurodegenerative disorders such as Parkinson
with lesser degree of complications and better efficacy and
outcome. Endometrial stem cells evaluated by using flow-
cytometery for detection of stem cell markers such as CD146,
CD90 in the isolated endometrial stem cells. Also, isolated
stromal cells will be examined to be free from hematopoietic
cells using CD34 staining. The next step was to investigate the
ability of human endometrial adult stem cells to differentiate
into the dopaminergic neurons showing characteristics of
dopaminergic neurons. For this purpose, the endometrial
stem cells induced by dopaminergic neurons differentiation
medium. Subsequently, immunocytochemistry used for the
confirmation of dopaminergic neurons markers expression
such as FOXA2 and GIRK2. Multipotent adult stem/
progenitor cells in the endometrium were characterized
by a remarkable regenerative capacity of undergoing
repetitive cycles of growth and differentiation. Endometrial
regenerative cells possess the potential to differentiate into
adipocytes, endothelial cells, pancreatic cells and neurons.
In the past few years, for neurodegenerative diseases
therapy, research has focused on the stem cells therapy.
Due to promising results in stem cell therapy, there are
different sources of stem cells for transplantation in human.
Recently, a highly promising source of accessible, abundant
and multipotent adult stem cells is human endometrial stem
cells. Consequently, we could that endometrial adult stem
cells differentiated into dopaminergic neurons when they
are exposed to specific differentiated conditions. The stem
cells have potential advantages over other stem cells and are
attractive candidate for treatment of Parkinson.
e:
Application of endometrial stem cells for Parkinson’s treatment
Armin Ai
Tehran University of Medical Sciences, Iran