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Journal of Diabetology | Volume 3
May 16-17, 2019 | Prague, Czech Republic
Diabetes and Endocrinology
27
th
International Conference on
J Diabetol, Volume 3
T
here is growing evidence of long-term remission
of type 2 diabetes after metabolic surgery (bariatric
surgery) however; the pathophysiology of improved glucose
metabolism after surgery remains poorly understood.
Bile acids are the main component of human bile and
have traditionally been considered mediators of lipid
absorption and cholesterol metabolism, facilitated by
their amphipathic nature. In recent years bile acids have
been identified as metabolic molecules which regulate
glycaemic control amongst other processes via activating
the nuclear receptor, farnesoid X receptor (FXR) and the G
protein-coupled membrane receptor (TGR5). Furthermore
the interplay between bile acids and incretin hormones
such as glucagon like peptite-1 (GLP-1) has given us new
insight into their collective contribution in improving
glycaemic control. Bile acid pool and composition are
altered following certain metabolic surgeries such as
Roux-en-Y gastric bypass (RYGB) and the post-prandial
GLP-1 responses are enhanced after RYGB. This session
will review our current understanding of these metabolic
regulators and the potential role they play in the remission
of type 2 diabetes mellitus after metabolic surgery.
Speaker Biography
RoyceVincent isaconsultantchemicalpathologistatKing’sCollegeHospital
NHS Foundation Trust and an Honorary Senior Lecturer at King’s College
London, UK. He has a special interest in nutrition and endocrinology and
is the clinical lead for biochemistry and parenteral nutrition services. He
obtained hisMD (Res) at Imperial College London and his research interests
are in obesity, endocrinology and clinical nutrition. He has published
multiple original and review articles and is serving as an international
editorial board member for Translational Metabolic Syndrome Research.
e:
royce.vincent@nhs.netRoyce Vincent
King’s College Hospital NHS Foundation Trust, United Kingdom
Remission of type 2 diabetes mellitus: Bile acid signalling and
incretins