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academies
Nov 22-23, 2018 | Paris, France
Joint Event
Nutrition and Health
16
th
International Conference on
26
th
International Conference on
Diabetes and Endocrinology
&
Journal of Insights in Nutrition and Metabolism | Volume 2
Grape juice consumption and/or exercise training increased brain-derived neurotrophic factor levels
in healthy elderly women
Caroline Dani
Methodist University Center, Brazil
B
rain-derived neurotrophic factor (BDNF) is the most widely
distributedneurotrophicfactorinthecentralnervoussystem
(CNS), and performs many biological functions such as neural
survival, differentiation, and plasticity, effecting in learning and
memory abilities. The grape juice effect was observed firstly
in rats, but there isn´t studies with humans and the potential
effect of exercise. This study aimed to verify the impact of
grape juice consumption and/or exercise in the modulation of
the plasma neurotrophic factor (BDNF) levels in healthy elderly
women. We designed this study in two steps. Firstly, 19 healthy
elderly womenwere randomly distributed in two groups: Grape
Juice Group (GJG, n=9) and Grape Juice + Exercise Group (GJEG,
n=10). TheGJGwas instructed todrunk daily the grape juice(400
ml) during 30 days, while the GJEG was submitted to a physical
exercise intervention (twice a week, 60 min/session) and drunk
the grape juice. Secondly, 20 women were randomized in two
groups: GJ + Exercise Group (GJEG, n=10) and Placebo + Exercise
Group (PEG, n=10). The consumption and exercise instructions
were the same. The grape juice and the placebo were provided
by the same winery, they were packed in the same box, with
the same information, blinding the study. The grape juice is
a commercial product. The placebo provided the same sugar
content than the grape juice but without polyphenols. Blood
sampling were taken for BDNF analysis pre/post intervention
in both groups. The total phenolic compounds and total
flavonols content were higher in grape juice than placebo.
It was observed a significant increase on BDNF levels in GJG)
and GJEG after intervention. However, this increasing was not
observed in placebo group with exercise. In conclusion, the
grape juice consumption per se is capable to increases BDNF
levels, response that was not potentiated by exercise practice.
Speaker Biography
Caroline Dani has completed her PhD in 2008 from Universidade de Caxias do Sul, Brazil.
She has completed her pos doc at Georgetown University, Washington, USA. She is
professor of Methodist University Center, IPA, Brazil. She is a master co-ordinator. She has
almost 80 publications. She is studying about grape juice since 2004. She has supervised
more than 20 master and graduation students.
e:
carolinedani@yahoo.com.br