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academies
Nov 22-23, 2018 | Paris, France
Joint Event
Nutrition and Health
16
th
International Conference on
26
th
International Conference on
Diabetes and Endocrinology
&
Journal of Insights in Nutrition and Metabolism | Volume 2
Clinical presentations, glycemic control, complications and associated autoimmune diseases among
children and adolescents with type 1 diabetes mellitus
Asmaa Milyani
King Abdulaziz University Hospital, Saudi Arabia
T
o study the correlation between initial presentation,
metabolic control,long-term complication and the
concomitant autoimmune diseases. In addition to exploring
the various risk factors that can impact the glycemic control in
children and adolescents with type 1 diabetes mellitus (T1DM).
Methods:
A retrospective cross-sectional study was conducted
on 461 patients including children and adolescents with T1DM,
who were followed up at the pediatric clinic at King Abdul Aziz
University Hospital from January 2004 to December 2016.
The medical records and laboratory findings in the hospital’s
electronic system of all patients were reviewed. Collected
data comprised of the primary disease presentation including
hyperglycemic and diabetic ketoacidosis (DKA) symptoms,
associated autoimmune diseases and consequent chronic
complications.
Results:
The mean patient age was 10.4 ± 4.8 years. A total of
62.1% and 27.9% initially presented with hyperglycemia and
DKA, respectively. Glycemic control did not significantly differ
between the pubertal and the pre-pubertal groups, although
the glycated hemoglobin A1C levels were higher in the pre-
pubertal group (62.3%) than in the pubertal group (37.7%).
Chronic complications were observed as follows: steatohepatitis
(11.1%), microalbuminuria (11%), dyslipidemia (10.3%) and
retinopathy (5.7%). Regarding the associated comorbidities,
vitamin D deficiency was present in 58.9% of children and was
significantly associated with gender (68.4% females and 51.9%
males), whereas autoimmune thyroiditis and celiac disease
were present in 20% and 8.2% of children, respectively.
Conclusion:
Pre-pubertal children exhibited less glycemic control
as compared to adolescents. The most common presentation at
diagnosis included signs of hyperglycemia rather than those of
DKA. The co morbidities showed a significant relationship with
gender. Vitamin D deficiency is the most common associated
medical condition in children with diabetes.
Speaker Biography
Asmaa Milyani is a humble student, a passionate physician and an aspiring researcher
with a prospering interest in the field of pediatrics.
e:
asmaamilyani@gmail.com