diabetes-conference-2019-scientifictracks

Note:

Journal of Diabetology | Volume 3

Page 18

July 25-26, 2019 | Amsterdam, Netherlands

OF EXCELLENCE

IN INTERNATIONAL

MEETINGS

YEARS

Diabetes Conference 2019

International Conference on

DIABETES, NUTRITION,

METABOLISM & MEDICARE

THE GLYCEMIC ROLE OF IMMATURE CAROB FRUIT ON

IN VITRO

Α-AMYLASE/Α-GLUCO-

SIDASE INHIBITION AND

IN VIVO

DIABETES-INDUCED RATS

Mousa Qasem

University of Malaya, Malaysia

n Yemen, the immature Carob Pods (ICP) have been traditionally used for the control of high blood glucose

levels in diabetics, but its hypoglycaemic activity has not yet been evaluated. The current study has assessed

the glycaemic properties of methanolic extract of ICP against

in vitro

key enzymes linked to type 2 diabe-

tes mellitus (amylase and glucosidase) and

in vivo

diabetes induced rats. To induced diabetes mellitus in rats,

55mg/kg streptozotocin and 210mg/kg nicotinamide were used to intraperitoneally injection of 24 male

Sprague-Dawley rats and distributed randomly into high dose (1000mg/kg extract, n=6) low dose (500mg/kg

extract, n=6) positive control (10mg/kg glibenclamide, n=6) and untreated diabetic control (5ml/kg distilled

water, n=6) groups. Subsequently, all groups have been treated with a single oral daily dose during 28 days

of the treatments. Further, a normal control group (n=6) has been added and receiving 5ml/kg distilled water.

The ICP have exerted an inhibitory effect against α-glucosidase (IC50 97.13±4.11µg/ml) and α-amylase (IC50:

92.99±0.22µg/ml) as compared to α-acarbose. In the diabetic-induced rats, high dose of ICP could decrease sig-

nificantly the fasting blood sugar as compared to the untreated diabetic control. In conclusion, the methanolic

extract of ICP could inhibit the

in vitro

α-amylase and α-glucosidase enzymes and exert a hypoglycemic effect

in diabetes-induced rats.

Mousa Qasem, J Diabetol 2019, Volume 3

Mousa Qasem is a Master student at Department of Pharmacy, Faculty of Medicine, University of Malaya. He is a researcher in phar-

macology and drug discovery, in the field of diabetes mellitus. He published an ISI article related to type 2 diabetes mellitus. He is

serving as a reviewer for reputed journals

“Scientific Reports, Chines Herbal Medicines (CHM) and Nutrition & Food Science”

BIOGRAPHY