dermatology-summit-wound-care-2019-posters

2 / 15

allied
academies
Page 51
Notes:
September 09-10, 2019 | Edinburgh, Scotland
2nd Global Summit on
3rd International Conference on
Dermatology and Cosmetology
Wound Care, Tissue Repair and Regenerative Medicine
Joint Event
&
Journal of Dermatology Research and Skin Care | Volume 3
Dermatol Res Skin Care, Volume 3
Randomized, blinded, split-face trial to assess the brightening efficacy of liquid crystal
retinol serum in two different concentrations, both in application treatment and with
sonophoresis
Malwina Zasada
Medical University of Lodz, Poland
Background: Retinol modulate the amount of melanin
in the epidermis by directly acting on melanocytes and
epidermal keratinocytes. Topical application of retinol
reduces the transport of melanosomes, which leads to rapid
loss of melanin through the skin. An appropriately designed
cosmetic product with retinol and regimen of treatment can
improve facial hyperpigmentation appearance with improved
tolerability.
Objective: We sought to evaluate the brightening efficacy and
tolerability using a 0.3% and 0.5% novel, liquid crystal formula
of retinol.
Methods: The formula of serums were applied once a day to
the face for a period of 12 weeks, N=37. The treatment with
sonophoresis were carried out once per week for 7 weeks,
N=16. Evaluation were conducted at days D(0) baseline and
after the treatment, D(84) and D(49), respectively. Multi
Probe Adapter (MPA) system and Fotomedicus imaging
system was used to assess the efficacy of treatments. The
VAS method enabled the results to be determined by three
independent specialists. The study was approved by the
Bioetic Commission No. RNN / 281/16 / KE 2017 and No. KE
/ 229/19.
Results: Skin hyperpigmentation and uneveness of color
of skin surface gradually decreased over the treatments,
both left and right part of the face. In VAS assessment skin
discoloration was reduced. Mild side effects appeared in
several cases, mainly after the first sonophoresis treatment
with 0.5% retinol and was more intense on the left part
(0.5%) during the whole application treatment. There were
no significance changes between left and right side of the face
(p<0.05).
Conclusions: Regular use of retinol both in application
and with sonophoresis results in brightening of the skin.
However, less hypersensitivity and lower intensity of side
events occurred on the right (0.3%) in the treatment with
sonophoresis. Moreover, the concentration of the retinol
does not significantly affect brightening of the skin. It could
suggest that formulas based on lower concentrations of
retinol might be used to offer comparable activity while
reducing the chance of side effect reactions.
Speaker Biography
MalwinaZasadaisaPhDstudentatMedicalUniversityofLodz.Sheisthefirst
author of original works in the field of cosmetic dermatology. She presents
the results of her research at national and international conferences. She
is a reviewer of scientific papers in cosmetics and dermatological journals.
Within her scientific interests are cosmetic formulation and application
therapy with active ingredients, i.e. niacinamide, vitamin C and retinol.
She is the author of her own cosmetic product, which she has subjected to
many tests, both in vivoand in vitro.
e: