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Dental Congress 2019 Journal of Clinical Dentistry and Oral Health | Volume 3
Page 39
OF EXCELLENCE
IN INTERNATIONAL
MEETINGS
YEARS
April 15-16, 2019 | Milan, Italy
DENTISTRY
AND ORAL HEALTH
2nd International Conference on
ASSOCIATION OF IL6 GENE POLYMORPHISMS WITH EXTERNAL ROOT RESORP-
TION IN REPLANTED TEETH AND ANALYSIS OF THE CLINICAL ASPECTS INVOLVED
LilianeRoskamp1, PaulaCristinaTrevilatto2, CleberMachadodeSouza2 and VâniaDitzelWestphalen2
1 Tuiuti University, Brazil
2 Universidade Católica do Paraná, Brazil
Introduction: The presence of resorption on the surface of the root of replanted teeth indicates an immune-in-
flammatory reaction. Cytokines that are codified by DNA, regulate the immune-inflammatory response of the
host. For this reason, it is important to analyze the management of tooth replantation and the genetic charac-
teristics of the patient in order to observe their contribution to the development of tooth resorption.
Aim: The Interleukin 6 (IL6) is an inflammatory marker, so this study investigates the association of clinical vari-
ables and polymorphisms in IL6 gene, with the outcome of replanted teeth.
Material & Methods: 94 patients who had their teeth replanted and treated endodontically were selected.
Periapical radiographs were taken soon after replantation and after one year. The DNA was collected to deter-
mine the IL6 gene polymorphisms. The analysis was performed by Real Time-PCR. Univariate and multivariate
statistical evaluation were used to associate the prognosis of the replanted teeth and their clinical and genetic
variables (p < 0.05).
Results: It was observed an association of age, extra-alveolar time and storage medium with root resorption
in a univariate analysis. The extra-alveolar time and the rs2069843 polymorphism of the IL6 gene were signifi-
cantly associated with root resorption in multivariate analysis.
Conclusions: The extra-alveolar time and the rs2069843 in IL6 gene were associated to the development of
root resorption in replanted teeth in the first-year post-trauma.
Liliane Roskamp et al., J Clin Dentistry Oral Health 2019, Volume 3
Liliane Roskamp has completed her PhD at the age of 53 from Pontificia Universidade Católica do Paraná, Brazil. She graduated
in Dentistry from the Federal University of Paraná and studied two academic years of Dentistry at Université libre de Bruxelles,
Belgium. She is specialist in Endodontics and Basic Immunology Clinic Epidemiology (Public Health) and Clinical Diagnostics and
Molecular. She has a Master’s and a PhD degree in Endodontics. She has experience in the area of Clinical Dentistry with emphasis
on Endodontics and Dental Traumatology. She is part time invited Professor at Tuiuti University, Pontifícia Universidade Católica
do Paraná and Faculdade Herrero. She works as part time reviewer for Journal of Periodontology , Archives of Oral Biology, Journal of
Inflammation Research, Jornal of the American Dental Association and Dental Traumatology. She has published more than 40 papers
in reputed journals and annals events.
BIOGRAPHY