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Dental Congress 2019 Journal of Clinical Dentistry and Oral Health | Volume 3
Page 45
OF EXCELLENCE
IN INTERNATIONAL
MEETINGS
YEARS
April 15-16, 2019 | Milan, Italy
DENTISTRY
AND ORAL HEALTH
2nd International Conference on
PENTOXIFYLLINE, TOCOPHEROL AND CLODRONATE COMBINATION FOR THE
PREVENTION AND TREATMENT OF OSTEORADIONECROSIS OF THE JAWS
Dorsaf Touil1, Belkacem Raouaa2, Oualha Lamia2 and Ki Nabiha 2
1 Sahloul University Hospital, Tunisia
2 University in Monastir, Tunisia
Osteoradionecrosis (ORN) of the jaw is a severe complication of radiotherapy for head and neck cancer. It’s
defined as an exposure of a necrotic bone that failed to heal within a period of 6 weeks. This condition can
lead to severe morbidity and definitely affects the quality of life of the patient. Over the last decades, several
therapeutic options were considered in the treatment of the ORN, including hyperbaric oxygen, antibiotics,
steroids and surgical resection with reconstruction. But none of them was considered to be efficient. Recently
a new treatment based on the theory of the radio-induced fibrosis has emerged. A combination of Pentoxifyl-
line-tocopherol and clodronate (PENTOCLO protocole) has proven efficacy in the prevention and/or the treat-
ment of ORN of the jaws. The objective of this presentation is to update the recommendations of the use of the
Pentoclo combination as a treatment modality in both prevention and treatment of ORN of the jaws. We will
be discussing the prescription modalities via three cases reports in which patients with different stages of ORN
of the jaws were treated successfully using the pentoclo protocole. In the second part of the presentation, we
will discuss the results of our systematic review of the literature (2018) in which the efficacy and the tolerance
of this protocole were reviewed.
Dorsaf Touil et al., J Clin Dentistry Oral Health 2019, Volume 3
Dorsaf Touil was graduated from the Dental Faculty of Monastir Tunisia, in 2013. She is specialist in Oral Medicine and Oral Surgery.
She is an Assistant Professor in the Department of Dentistry in University Hospital Sahloul from April 2015. She is the Founding
Member of the Tunisian Association of the specialists in Oral Surgery and Oral Medicine and Association Ttunisienne des Médecins
Dentistes Spécialistes en Médecine et Chirurgie Buccales. She is also author and co-Author of many scientific publications in French
and English. She has participated as speaker in many international scientific events during 2016-2018.
BIOGRAPHY