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Journal of Neurology and Neurorehabilitation Research | Volume: 3
August 16-17, 2018 | Copenhagen, Denmark
Dementia and Alzheimer ’s Disease
10th World congress on
Emerging evidence suggested a link between Obstructive
SleepApnea(OSA)andcognitivedecline,includingdementia.
The severity of cognitive impairment has been reported to be
directly correlated with the degree of OSA. Neurodegenerative
changes and vascular diseases are significant comorbidities on
report theoccurrenceof OSA inpatientswith
dementia in the Island of Guam and to correlate the severity
of OSA with the results of the neuropsychological testing
and neuroimaging studies. We also report the prevalence of
comorbid vascular diseases in these patients. A retrospective
analysis of medical records of patients evaluated at Neurology
Clinic with the diagnosis of OSA and dementia from August
2006 to June 2016 was conducted. There were 359 patients
with dementia and 17% have been diagnosed with OSA.
Among patients with OSA, 45% have moderate to severe OSA
withmoderate degree of cerebral atrophy on the neuroimaging
studies and 17% have mild OSA with mild degree of cerebral
atrophy. 17% of patients with moderate to severe OSA have
moderate impairment on global cognitive scores and 17% with
mild OSA have mild impairment on global cognitive scores. 25%
of patients with moderate to severe OSA have stroke and 17%
have leukoaraiosis in the neuroimaging studies. The prevalence
of vascular diseases on patients with moderate to severe
dementia showed that 75%, 58%, 66% and 33% of patients
have hypertension, diabetes mellitus, hyperlipidemia and heart
diseases, respectively, Wherein patients with mild dementia,
hypertension, diabetes mellitus, hyperlipidemia and heart
diseases were identified on 70%, 54%, 60%and 30%of patients,
respectively. Conclusion: OSA is a common sleep disturbance in
patients with dementia. The severity of OSA correlates closely
with the degree of cerebral atrophy and global cognitive scores.
Various comorbid vascular diseases are frequently encountered
in patients with OSA and dementia.
Speaker Biography
Ramel Carlos is a Board Certified Neurologist. He is currently working at Neurology
Clinic in Tamuning, Guam. He completed his Residency and fellowship training at Wake
Forest University, Winston-Salem, North Carolina.
e:
Ramel Carlos
Neurology Clinic, USA
Obstructive sleep apnea in Dementia