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Case Reports in Surgery and Invasive Procedures | Volume 3
March 11-12, 2019 | London, UK
Biomarkers
Plastic and Cosmetic Surgery
International Conference on
International Conference on
Joint Event
&
Urine - The next generation early disease biomarker source
Youhe Gao
Beijing Normal University, China
H
ow to find the early sensitive biomarker is the most
important question for medicine. Biomarker is the
measurable change associated with the disease. Without
homeostatic control, urine accumulates many early changes
therefore theoretically is a better biomarker source than blood.
Disease animal models were used to limit the confounding
factors to minimum. Early candidate biomarkers were found in
many disease models including type2 diabetes, lung fibrosis,
liver fibrosis, chronic pancreatitis, chronic obstructive pulmonary
disease, multiple sclerosis, myocarditis, subcutaneous cancer
model, bacterial meningitis, astrocytoma cancer model, patient
derived xenograph model, Alzheimer disease etc. Relatively
significant percentage of those candidate biomarkers had been
reported to related to the disease. And many early biomarkers
appeared earlier than clinical symptom, than MRI imaging, than
significant pathological changes. Preservation of urine samples
onmembranewill also be discussed. This simple and economical
method will greatly speed up the urinary biomarker discovery
and validation.
e:
youhegao@163.com