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Journal of Neurology and Neurorehabilitation Research | Volume 3
allied
academies
Nov12-13, 2018 | Paris, France
Central Nervous System & Therapeutics
International Conference on
The Myelin is very abundant in brain and recent research
highlights its role as an energetic support for the axon,
quite different from the traditional one. Myelin incorporates
many molecular devices typical of mitochondria and aerobically
produces ATP better than mitochondria. It has been shown that
axonal firing determines a transient drop in Myelin ATP and
suggestive hypotheses can be formulated about an important
role of myelin in memory and in general in support of cognitive
abilities. The alteration of mitochondria as a triggering cause of
Multiple Sclerosis (MS) is confirmed because myelin appears to
derive from mitochondria, probably due to membrane fusion
processes. As far asMS is concerned, promising nutritional and/
or pharmacological approaches that support myelin growth and
turnover appear promising: i) integration with high doses of
vitaminD, aknown trophicagent formitochondriaand therefore
also for myelin; ii) food supplementation with galactose, a sugar
that appears functional to myelin growth; iii) integration with
Biotin and fumarate esters, which support the anaplerotic
processes of themyelin, feeding Krebs cycle. In the brainmyelin
is enriched in the enzyme Carbonic Anhydrase (containing the
essential metal Zinc), demonstrative of the active combustion
operating inside it. Myelin has also an active synthesis of the
hemegroup,whichensuresagood functioningof therespiratory
complexes. A link between heavy metal pollution (lead in
particular) and neurodegenerative diseases is evident: Lead can
replace Zn in the pathway of heme synthesis (inhibiting delta-
Aminolevulinic acid dehydratase). The increased incidence of
multiplesclerosisintheSardiniaregion(Italy),whichcouldderive
from the millenary mining activity of lead mining, is interesting.
Speaker Biography
Alessandro Morelli is working as a professor on Biological Chemistry University of
Genova, School of Medical and Pharmaceutical Sciences,DIFAR-Dept of Pharmacy
- Biochemistry worked as an associate professor at the Faculty of Medicine
(before) and full professor (1986) to the Faculty of Science, has been owner of many
of Biological Chemistry courses. He coordinated the Interdisciplinary Laboratory for
Experimental Biology II, expressing particular passion and competence for teaching
was the President of the Paritectic Commission (Professors-Students)
for Education and the Right to Study (2005-2008) for University of Genoa and held
the office of President of the Degree Course in Biological Sciences (2009-2012).
e:
Alessandro Morelli
Genova University, Italy
The bioenergetic role for Myelin suggest new approach to therapeutic of Multiple
Sclerosis